| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5138538 | B | Inhibition of human recombinant full-length DNMT1 expressed in Sf9 cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 18 | ALA5137006 | cell-based format | Scientific Literature | |
| 2. | ALA5138539 | B | Inhibition of human C-terminal domain DNMT1 catalytic domain (351 to 1600 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells assessed as inhibition of methylated dI-dC formation using 1 ug/ml poly dI-dC and [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature | |
| 3. | ALA5138540 | B | Inhibition of human C-terminal domain DNMT1 catalytic domain (351 to 1600 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells assessed as inhibition of methylated dI-dC formation using 5 ug/ml poly dI-dC and [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature | |
| 4. | ALA5138541 | B | Inhibition of human C-terminal domain DNMT1 catalytic domain (351 to 1600 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells assessed as inhibition of methylated dI-dC formation using 25 ug/ml poly dI-dC and [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature | |
| 5. | ALA5138542 | B | Inhibition of human C-terminal domain DNMT1 catalytic domain (351 to 1600 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and 1 uM [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature | |
| 6. | ALA5138543 | B | Inhibition of human C-terminal domain DNMT1 catalytic domain (351 to 1600 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and 4 uM [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature | |
| 7. | ALA5138544 | B | Inhibition of human C-terminal domain DNMT1 catalytic domain (351 to 1600 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and 6 uM [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature | |
| 8. | ALA5138545 | B | Inhibition of human C-terminal domain DNMT1 catalytic domain (351 to 1600 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and 8 uM [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature | |
| 9. | ALA5138546 | B | Inhibition of human C-terminal domain DNMT1 catalytic domain (351 to 1600 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and 12 uM [Me-3H]SAM as substrate incubated for 2 hrs by liquid scintillation counting analysis | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature | |
| 10. | ALA5138547 | B | Binding affinity to human C-terminal domain DNMT1 catalytic domain (446 to 1616 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells by ultrafiltration binding assay | Homo sapiens | 1 | ALA5137006 | cell-based format | Scientific Literature | |
| 11. | ALA5138548 | B | Inhibition of human C-terminal domain DNMT3b catalytic domain (568 to 853 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and [Me-3H]SAM as substrate incubated for 45 mins in presence of DNMT3L by liquid scintillation counting analysis | Homo sapiens | 7 | ALA5137006 | cell-based format | Scientific Literature | |
| 12. | ALA5138549 | B | Selectivity ratio of IC50 for human C-terminal domain DNMT3b catalytic domain (568 to 853 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells to IC50 for human recombinant full-length DNMT1 expressed in Sf9 cells | Homo sapiens | 5 | ALA5137006 | cell-based format | Scientific Literature |
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