# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5158206 | A | Metabolic stability in C57BL/6 mouse liver microsomes assessed as half life | Mus musculus | 5 | ALA5154715 | microsome format | Scientific Literature | |
2. | ALA5158207 | A | Metabolic stability in C57BL/6 mouse liver microsomes assessed as parent compound remaining incubated for 120 mins | Mus musculus | 5 | ALA5154715 | microsome format | Scientific Literature | |
3. | ALA5158208 | B | Agonist activity at human PPARdelta transfected in HEK293 cells assessed as relative luciferase unit at 50 uM measured after 16 hrs by luciferase reporter gene assay | Homo sapiens | 13 | ALA5154715 | cell-based format | Scientific Literature | |
4. | ALA5158209 | B | Agonist activity at human PPARalpha transfected in HEK293 cells assessed as relative luciferase unit at 50 uM measured after 16 hrs by luciferase reporter gene assay | Homo sapiens | 17 | ALA5154715 | cell-based format | Scientific Literature | |
5. | ALA5158210 | B | Agonist activity at human PPARgamma transfected in HEK293 cells assessed as relative luciferase unit at 50 uM measured after 16 hrs by luciferase reporter gene assay | Homo sapiens | 11 | ALA5154715 | cell-based format | Scientific Literature | |
6. | ALA5158211 | B | Agonist activity at human PPARgamma in mouse 3T3-L1 cells assessed as induction of adipogenic differentiation at 25 uM measured after 11 days by Oil Red O staining analysis | Mus musculus | 5 | ALA5154715 | cell-based format | Scientific Literature | |
7. | ALA5158216 | B | Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay | Homo sapiens | 18 | ALA5154715 | cell-based format | Scientific Literature | |
8. | ALA5158217 | B | Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay | Homo sapiens | 14 | ALA5154715 | cell-based format | Scientific Literature | |
9. | ALA5158218 | B | Agonist activity at human PPARdelta expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay | Homo sapiens | 12 | ALA5154715 | cell-based format | Scientific Literature | |
10. | ALA5158219 | B | Agonist activity at human PPARalpha expressed in HEK293 cells assessed as maximal activity by luciferase/beta-galactosidase reporter gene assay relative to GW7647 | Homo sapiens | 18 | ALA5154715 | cell-based format | Scientific Literature | |
11. | ALA5158220 | B | Agonist activity at human PPARgamma expressed in HEK293 cells assessed as maximal activity by luciferase/beta-galactosidase reporter gene assay relative to rosiglitazone | Homo sapiens | 13 | ALA5154715 | cell-based format | Scientific Literature | |
12. | ALA5158221 | B | Agonist activity at human PPARdelta expressed in HEK293 cells assessed as maximal activity by luciferase/beta-galactosidase reporter gene assay relative to GW0742 | Homo sapiens | 12 | ALA5154715 | cell-based format | Scientific Literature | |
13. | ALA5158224 | B | Agonist activity at human PPARalpha in mouse hepatocytes assessed as induction of Fgf21 mRNA expression at 50 uM incubated for 16 hrs by quantitative real-time PCR analysis | Mus musculus | 13 | ALA5154715 | cell-based format | Scientific Literature | |
14. | ALA5158225 | B | Agonist activity at human PPARalpha in mouse hepatocytes assessed as induction of Pdk4 mRNA expression at 50 uM incubated for 16 hrs by quantitative real-time PCR analysis | Mus musculus | 13 | ALA5154715 | cell-based format | Scientific Literature | |
15. | ALA5158249 | F | In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in brain at 0.7 uM measured after 14 days by microscopy | Danio rerio | 2 | ALA5154715 | organism-based format | Scientific Literature | |
16. | ALA5158250 | B | Stabilization of human PPARalpha LBD assessed as change in melting temperature at 25 uM by thermal shift assay | Homo sapiens | 6 | ALA5154715 | single protein format | Scientific Literature | |
17. | ALA5158251 | B | Stabilization of human PPARgamma LBD assessed as change in melting temperature at 25 uM by thermal shift assay | Homo sapiens | 6 | ALA5154715 | single protein format | Scientific Literature | |
18. | ALA5158252 | B | Stabilization of human PPARdelta LBD assessed as change in melting temperature at 25 uM by thermal shift assay | Homo sapiens | 5 | ALA5154715 | single protein format | Scientific Literature |