| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5144715 | B | Inhibition of recombinant human HDAC1 expressed in baculovirus infection system using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 2. | ALA5144716 | B | Inhibition of recombinant HDAC6 (unknown origin) using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 3. | ALA5144717 | B | Inhibition of GLP (unknown origin) | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 4. | ALA5144718 | F | Antiproliferative activity against human A-431 cells measured after 72 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA5144719 | F | Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 6. | ALA5144720 | F | Antiproliferative activity against human HeLa cells measured after 72 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 7. | ALA5144721 | F | Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 8. | ALA5144722 | F | Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 9. | ALA5144723 | F | Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 10. | ALA5144724 | F | Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 11. | ALA5144725 | T | Cytotoxicity against human HL7702 cells measured after 72 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 12. | ALA5144726 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM measured after 5 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | microsome format | Scientific Literature | ||
| 13. | ALA5144727 | F | Induction of apoptosis in human HepG2 cells assessed as increase in cleaved PARP expression at 1.25 to 20 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5144728 | F | Induction of apoptosis in human HepG2 cells assessed as increase in cleaved caspase-3 expression at 1.25 to 20 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5144729 | B | Inhibition of GLP in human HepG2 cells assessed as reduction in H3K9Me2 expression at 1.25 to 20 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5144730 | B | Inhibition of HDAC in human HepG2 cells assessed as increase in Ac-H3K9 expression at 1.25 to 20 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5144731 | T | Effect on H3 expression in human HepG2 cells at 1.25 to 25 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5144732 | F | Induction of apoptosis in human HepG2 cells assessed as viable cells at 1.25 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 88.58%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5144733 | F | Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 1.25 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 6.87%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5144734 | F | Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 1.25 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 4.55%) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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