# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5152828 | Functional | Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs by CCK-8 assay | Homo sapiens | 11 | ALA5150032 | cell-based format | Scientific Literature | |
2. | ALA5152829 | Functional | Antiproliferative activity against human K562 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs by CCK-8 assay | Homo sapiens | 11 | ALA5150032 | cell-based format | Scientific Literature | |
3. | ALA5152830 | Functional | Antiproliferative activity against human A498 cells assessed as reduction in cell viability at 20 uM incubated for 24 hrs by CCK-8 assay | Homo sapiens | 11 | ALA5150032 | cell-based format | Scientific Literature | |
4. | ALA5152831 | Functional | Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay | Homo sapiens | 4 | ALA5150032 | cell-based format | Scientific Literature | |
5. | ALA5152832 | Functional | Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay | Homo sapiens | 4 | ALA5150032 | cell-based format | Scientific Literature | |
6. | ALA5152833 | Functional | Antiproliferative activity against human A498 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay | Homo sapiens | 4 | ALA5150032 | cell-based format | Scientific Literature | |
7. | ALA5152834 | Toxicity | Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth | Homo sapiens | 2 | ALA5150032 | cell-based format | Scientific Literature | |
8. | ALA5152835 | Binding | PROTAC activity at VHL/GSPT1 in human HL-60 cells assessed as effect on GSPT1 protein level at 20 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA5150032 | cell-based format | Scientific Literature | |
9. | ALA5152836 | Binding | PROTAC activity at VHL/GSPT1 in human K562 cells assessed as effect on GSPT1 protein level at 20 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA5150032 | cell-based format | Scientific Literature | |
10. | ALA5152837 | Binding | PROTAC activity at VHL/GSPT1 in human A498 cells assessed as effect on GSPT1 protein level at 20 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA5150032 | cell-based format | Scientific Literature | |
11. | ALA5152838 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 10 to 20 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
12. | ALA5152839 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 10 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
13. | ALA5152840 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 10 uM by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
14. | ALA5152841 | Binding | PROTAC activity at VHL/c-KIT in human HL-60 cells assessed as reduction in c-KIT protein level at >10 uM measured at 24 to 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
15. | ALA5152842 | Binding | PROTAC activity at VHL/FLT-3 in human K562 cells assessed as reduction in FLT-3 protein level at 20 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 2 | ALA5150032 | cell-based format | Scientific Literature | |
16. | ALA5152844 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 1 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
17. | ALA5152845 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 20 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
18. | ALA5152846 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 20 uM preincubated with MG-132 for 1 hrs followed by compound addition and measured after for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
19. | ALA5152847 | Binding | PROTAC activity at VHL/FLT-3 in human HL-60 cells assessed as reduction in FLT-3 protein level at 20 uM preincubated with VHL032 for 1 hrs followed by compound addition and measured after for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature | |
20. | ALA5152848 | Binding | PROTAC activity at VHL/c-KIT in human HL-60 cells assessed as reduction in c-KIT protein level at 20 uM preincubated with VHL032 for 1 hrs followed by compound addition and measured after for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5150032 | cell-based format | Scientific Literature |