# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5141806 | B | Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microplate reader analysis | Homo sapiens | 38 | single protein format | Scientific Literature | ||
2. | ALA5141807 | B | Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microplate reader analysis | Homo sapiens | 38 | single protein format | Scientific Literature | ||
3. | ALA5141808 | P | Solubility of the compound in simulated intestinal fluid at upto 200 uM by HPLC-UV analysis | 14 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA5141809 | P | Solubility of the compound in PBS at pH 7.4 at upto 200 uM by HPLC-UV analysis | 14 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA5141810 | P | Solubility of the compound in simulated gastric fluid at upto 200 uM by HPLC-UV analysis | 14 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA5141811 | A | Metabolic stability in rat hepatocytes assessed as intrinsic clearance | Rattus norvegicus | 14 | cell-based format | Scientific Literature | ||
7. | ALA5141812 | A | Plasma protein binding in human | Homo sapiens | 14 | cell-free format | Scientific Literature | ||
8. | ALA5141813 | A | Plasma protein binding in rat | Rattus norvegicus | 14 | cell-free format | Scientific Literature | ||
9. | ALA5141814 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
10. | ALA5141815 | A | Apparent permeability across basolateral to apical side in human Caco-2 cells | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
11. | ALA5141816 | A | Metabolic stability in human hepatocytes assessed as half life | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
12. | ALA5141817 | A | Metabolic stability in rat hepatocytes assessed as half life | Rattus norvegicus | 14 | cell-based format | Scientific Literature | ||
13. | ALA5141818 | A | Metabolic stability in human hepatocytes assessed as intrinsic clearance | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
14. | ALA5141819 | F | Inhibition of serotonin formation in human BON cells assessed as reduction in intracellular serotonin levels incubated for 72 hrs by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA5141820 | A | AUCinfinity in ICR mouse plasma at 50 mg/kg, po administered as single dose measured for 1440 mins by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
16. | ALA5141821 | A | AUCinfinity in ICR mouse brain at 50 mg/kg, po administered as single dose measured for 1440 mins by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA5141822 | F | Inhibition of serotonin production in C57BL/6N mouse assessed as reduction in serotonin levels in duodenum at 20 to 200 mg/kg/day, po administered twice daily for 7 days by HPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA5141823 | F | Inhibition of serotonin production in C57BL/6N mouse assessed as reduction in serotonin levels in brain at 20 to 200 mg/kg/day, po administered twice daily for 7 days by HPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
19. | ALA5141824 | F | Inhibition of dopamine production in C57BL/6N mouse assessed as reduction in dopamine levels in brain at 20 to 200 mg/kg/day, po administered twice daily for 7 days by HPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
20. | ALA5141825 | F | Inhibition of tyrosine production in C57BL/6N mouse assessed as reduction in tyrosine levels in liver at 20 to 200 mg/kg/day, po administered twice daily for 7 days by HPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature |