# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5158572 | F | Antiviral activity against lamivudine/entecavir-resistant Hepatitis B virus infected in human HepG2 A64 cells assessed as inhibition of DNA replication at 1 uM incubated for 72 hrs by RT PCR analysis | Hepatitis B virus | 2 | organism-based format | Scientific Literature | ||
2. | ALA5158573 | F | Antiviral activity against wild type Hepatitis B virus infected in human HepG2.2.2.15 cells assessed as inhibition of DNA replication at 1 uM incubated for 72 hrs by RT PCR analysis | Hepatitis B virus | 2 | organism-based format | Scientific Literature | ||
3. | ALA5158574 | T | Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as reduction in cell growth by CCK8 assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
4. | ALA5158575 | B | Agonist activity at human TLR8 expressed in HEK293T cells co-transfected with NFKappaB luciferase and renilla plasmids assessed as NF-kappaB activation measured after 48 hrs by dual-luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA5158576 | T | Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as inhibition of cell growth at 0.4 uM incubated for 6 days by RT PCR analysis relative to control | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
6. | ALA5158577 | F | Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells assessed as inhibition of DNA replication | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
7. | ALA5158578 | T | Selectivity index, ratio of CC50 for human HepG2.2.2.15 cells to IC50 for Hepatitis B virus infected in human HepG2.2.2.15 cells | 8 | cell-based format | Scientific Literature | |||
8. | ALA5158579 | F | Antiviral activity against lamivudine/entecavir- resistant Hepatitis B virus infected in human HepG2 A64 cells assessed as inhibition of DNA replication | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
9. | ALA5158580 | T | Selectivity index, ratio of CC50 for human HepG2.2.2.15 cells to IC50 for lamivudine/entecavir-resistant Hepatitis B virus infected in human HepG2 A64 cells | 2 | cell-based format | Scientific Literature |