| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5138944 | B | Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 2. | ALA5138945 | B | Inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 3. | ALA5138946 | B | Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 4. | ALA5138947 | B | Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 5. | ALA5138948 | B | Inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 6. | ALA5138949 | B | Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 7. | ALA5138950 | B | Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 8. | ALA5138951 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 9. | ALA5138952 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 10. | ALA5138953 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 11. | ALA5138954 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 12. | ALA5138955 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 13. | ALA5138956 | B | Selectivity index, ratio of IC50 for human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 14. | ALA5138963 | B | Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as dissociation constant by surface plasmon resonance | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 15. | ALA5138964 | B | Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as binding constant (Kon) by surface plasmon resonance analysis | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 16. | ALA5138965 | B | Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as binding constant (Koff) by surface plasmon resonance analysis | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 17. | ALA5138966 | B | Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as in vitro residence time by surface plasmon resonance analysis | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 18. | ALA5138967 | A | Apparent permeability of the compound in phosphate buffer at pH 7.4 measured after 24 hrs by PAMPA assay | 5 | assay format | Scientific Literature | |||
| 19. | ALA5138968 | T | Cytotoxicity against human HEK293T cells assessed as cell viability at 10 to 100 uM incubated for 24 to 72 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA5138969 | T | Cytotoxicity against human HEK293T cells assessed as cell viability at 10 to 100 uM measured after 72 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature |
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