# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5163495 | F | Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis | Homo sapiens | 34 | ALA5154830 | cell-based format | Scientific Literature | |
2. | ALA5163496 | F | Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis | Homo sapiens | 21 | ALA5154830 | cell-based format | Scientific Literature | |
3. | ALA5163497 | B | Selectivity ratio of EC50 for beta1 adrenoceptor (unknown orgin) expressed in HEK293 cells to EC50 for human beta2 adrenoceptor (unknown orgin) expressed in HEK293 cells | Homo sapiens | 21 | ALA5154830 | cell-based format | Scientific Literature | |
4. | ALA5163498 | F | Relaxant activity in Hartley guinea pig tracheal strips model of histamine-induced smooth muscle contraction at 8 x 10^-6 mol/L relative to control | Cavia porcellus | 19 | ALA5154830 | assay format | Scientific Literature | |
5. | ALA5163499 | F | Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 9 ug/kg, iv measured after 1 min by Konzett-Roessler methodology relative to control | Oryctolagus cuniculus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
6. | ALA5163500 | F | Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 3 ug/kg, iv measured after 1 min by Konzett-Roessler methodology relative to control | Oryctolagus cuniculus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
7. | ALA5163501 | F | Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 1 ug/kg, iv measured after 1 min by Konzett-Roessler methodology relative to control | Oryctolagus cuniculus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
8. | ALA5163502 | F | Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 9 ug/kg, iv measured after 30 mins by Konzett-Roessler methodology relative to control | Oryctolagus cuniculus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
9. | ALA5163503 | F | Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 3 ug/kg, iv measured after 30 mins by Konzett-Roessler methodology relative to control | Oryctolagus cuniculus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
10. | ALA5163504 | F | Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 1 ug/kg, iv measured after 30 mins by Konzett-Roessler methodology relative to control | Oryctolagus cuniculus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
11. | ALA5163505 | F | Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 9 ug/kg, iv measured after 45 mins by Konzett-Roessler methodology relative to control | Oryctolagus cuniculus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
12. | ALA5163506 | F | Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 3 ug/kg, iv measured after 45 mins by Konzett-Roessler methodology relative to control | Oryctolagus cuniculus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
13. | ALA5163507 | F | Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 1 ug/kg, iv measured after 45 mins by Konzett-Roessler methodology relative to control | Oryctolagus cuniculus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
14. | ALA5163508 | F | Antiinflammatory activity in Sprague- Dawley rat model of ovalbumin induced allergic asthma assessed as reduction in histamine release from lung fragments at 10^-2 umol/L administered 5 mins prior to allergen challenge and measured after 10 mins | Rattus norvegicus | 1 | ALA5154830 | organism-based format | Scientific Literature | |
15. | ALA5163509 | F | Antiinflammatory activity in Sprague-Dawley rat model of ovalbumin induced allergic asthma assessed as reduction in histamine release from lung fragments at 10^-1 umol/L administered 5 mins prior to allergen challenge and measured after 10 mins | Rattus norvegicus | 1 | ALA5154830 | organism-based format | Scientific Literature | |
16. | ALA5163510 | F | Antiinflammatory activity in Sprague- Dawley rat model of ovalbumin induced allergic asthma assessed as reduction in histamine release from lung fragments at 1 umol/L administered 5 mins prior to allergen challenge and measured after 10 mins | Rattus norvegicus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
17. | ALA5163512 | F | Antiinflammatory activity in Sprague- Dawley rat model of ovalbumin induced allergic asthma assessed as reduction in histamine release from lung fragments at 10^-2 umol/L administered 5 mins prior to allergen challenge and measured after 10 mins in presence of propranolol | Rattus norvegicus | 1 | ALA5154830 | organism-based format | Scientific Literature | |
18. | ALA5163513 | F | Antiinflammatory activity in Sprague- Dawley rat model of ovalbumin induced allergic asthma assessed as reduction in histamine release from lung fragments at 10^-1 umol/L administered 5 mins prior to allergen challenge and measured after 10 mins in presence of propranolol | Rattus norvegicus | 1 | ALA5154830 | organism-based format | Scientific Literature | |
19. | ALA5163514 | F | Antiinflammatory activity in Sprague- Dawley rat model of ovalbumin induced allergic asthma assessed as reduction in histamine release from lung fragments at 1 umol/L administered 5 mins prior to allergen challenge and measured after 10 mins in presence of propranolol | Rattus norvegicus | 2 | ALA5154830 | organism-based format | Scientific Literature | |
20. | ALA5163515 | F | Relaxant activity in guinea pig smooth muscle cells assessed as decrease in intracellular calcium level at 1 umol/L incubated for 5 mins by Flura2AM staining based fluorescence assay | Cavia porcellus | 2 | ALA5154830 | cell-based format | Scientific Literature |