# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5140066 | B | Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by ATP addition and measured after 30 mins by ELISA | Mus musculus | 29 | ALA5137033 | cell-based format | Scientific Literature | |
2. | ALA5140067 | T | Cytotoxicity against mouse J774.A1 cells assessed as cell viability at 10 uM incubated for 4 hrs by MTT assay relative to control | Mus musculus | 29 | ALA5137033 | cell-based format | Scientific Literature | |
3. | ALA5140068 | T | Cytotoxicity against HEK293 cells assessed as cell viability at 10 uM incubated for 4 hrs by MTT assay relative to control | Homo sapiens | 29 | ALA5137033 | cell-based format | Scientific Literature | |
4. | ALA5140069 | B | Inhibition of NLRC4 inflammasome in LPS-primed mouse J774.A1 cells assessed as IL-1beta secretion at 10 uM preincubated for 1 hr followed by flagellin addition and measured after 6 hrs by ELISA relative to control | Mus musculus | 15 | ALA5137033 | cell-based format | Scientific Literature | |
5. | ALA5140070 | B | Inhibition of AIM2 inflammasome in LPS-primed mouse J774.A1 cells assessed as IL-1beta secretion at 10 uM preincubated for 1 hr followed by poly(dA:dT) addition and measured after 4 hrs by ELISA relative to control | Mus musculus | 15 | ALA5137033 | cell-based format | Scientific Literature |