# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5163214 | Binding | Inhibition of alpha2c adrenergic receptor (unknown origin) | Homo sapiens | 4 | ALA5154826 | single protein format | Scientific Literature | |
2. | ALA5163232 | Binding | Inhibition of PRC2 (unknown origin) assessed as reduction in H3K27 trimethylation using H3K27Me0 peptide (21 to 44 residues) as substrate by measuring SAH formation by LC-MS analysis | Homo sapiens | 15 | ALA5154826 | assay format | Scientific Literature | |
3. | ALA5163235 | Binding | Inhibition of PRC2 in human G-401 cells assessed as H3K27 methylation status incubated for 48 hrs by ELISA method | Homo sapiens | 8 | ALA5154826 | cell-based format | Scientific Literature | |
4. | ALA5163236 | Functional | Antiproliferative activity against human KARPAS-422 cells expressing EZH2 mutant assessed as inhibition of cell growth after 14 days by beckman coulter counting method | Homo sapiens | 5 | ALA5154826 | cell-based format | Scientific Literature | |
5. | ALA5163237 | Physicochemical | Lipophilicity, logD of the compound at pH 7.4 by LC with tandem MS analysis | 5 | ALA5154826 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA5163238 | Physicochemical | Dissociation constant, pKa of compound | 4 | ALA5154826 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5163239 | Physicochemical | High throughput solubility of the compound at pH 6.8 after 16 to 24 hrs by MS/MS analysis | 9 | ALA5154826 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5163245 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | ALA5154826 | microsome format | Scientific Literature | |
9. | ALA5163246 | ADME | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | ALA5154826 | microsome format | Scientific Literature | |
10. | ALA5163247 | ADME | Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 11 | ALA5154826 | microsome format | Scientific Literature | |
11. | ALA5163248 | Binding | Inhibition of human Phosphodiesterase 4D | Homo sapiens | 4 | ALA5154826 | single protein format | Scientific Literature |