# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5121992 | B | Inhibition of ALK2 R206H mutant (unknown origin) assessed as enzymatic activity by microfluidic mobility shift assay | Homo sapiens | 21 | ALA5120784 | single protein format | Scientific Literature | |
2. | ALA5121993 | B | Inhibition of ALK2 R206H mutant (unknown origin) transfected in BMP6-stimulated human HEK293 cells by luciferase reporter gene assay | Homo sapiens | 21 | ALA5120784 | cell-based format | Scientific Literature | |
3. | ALA5121994 | P | Aqueous solubility of compound at pH 6.8 | 21 | ALA5120784 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5121995 | A | Permeability of compound by PAMPA assay | 21 | ALA5120784 | assay format | Scientific Literature | ||
5. | ALA5121996 | A | Microsomal stability in mouse liver microsomes assessed as clearance | Mus musculus | 21 | ALA5120784 | microsome format | Scientific Literature | |
6. | ALA5121997 | B | Inhibition of wild type ALK2 (unknown origin) assessed as enzymatic activity by microfluidic mobility shift assay | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature | |
7. | ALA5121998 | B | Inhibition of wild type ALK1 (unknown origin) assessed as enzymatic activity by microfluidic mobility shift assay | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature | |
8. | ALA5121999 | B | Inhibition of wild type ALK3 (unknown origin) assessed as enzymatic activity using chemiluminescent substrate by ADP-Glo assay | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature | |
9. | ALA5122000 | B | Inhibition of wild type ALK5 (unknown origin) assessed as enzymatic activity by microfluidic mobility shift assay | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature | |
10. | ALA5122001 | B | Inhibition of wild type ALK6 (unknown origin) assessed as enzymatic activity using chemiluminescent substrate by ADP-Glo assay | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature | |
11. | ALA5122002 | B | Selectivity ratio of IC50 for inhibition of wild type ALK2 (unknown origin) to IC50 for inhibition of ALK2 R206H mutant (unknown origin) | Homo sapiens | 1 | ALA5120784 | assay format | Scientific Literature | |
12. | ALA5122003 | B | Selectivity ratio of IC50 for inhibition of wild type ALK1 (unknown origin) to IC50 for inhibition of ALK2 R206H mutant (unknown origin) | Homo sapiens | 1 | ALA5120784 | assay format | Scientific Literature | |
13. | ALA5122004 | B | Selectivity ratio of IC50 for inhibition of wild type ALK3 (unknown origin) to IC50 for inhibition of ALK2 R206H mutant (unknown origin) | Homo sapiens | 1 | ALA5120784 | assay format | Scientific Literature | |
14. | ALA5122005 | B | Selectivity ratio of IC50 for inhibition of wild type ALK5 (unknown origin) to IC50 for Inhibition of ALK2 R206H mutant (unknown origin) | Homo sapiens | 1 | ALA5120784 | assay format | Scientific Literature | |
15. | ALA5122006 | B | Selectivity ratio of IC50 for inhibition of wild type ALK6 (unknown origin) to IC50 for inhibition of ALK2 R206H mutant (unknown origin) | Homo sapiens | 1 | ALA5120784 | assay format | Scientific Literature | |
16. | ALA5122007 | B | Binding affinity to wild type ALK6 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature | |
17. | ALA5122008 | B | Binding affinity to wild type ALK2 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature | |
18. | ALA5122009 | B | Binding affinity to wild type ALK1 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature | |
19. | ALA5122010 | B | Binding affinity to wild type ALK3 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature | |
20. | ALA5122011 | B | Binding affinity to wild type STK38 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA5120784 | single protein format | Scientific Literature |