# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5140448 | B | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 10 mins by Ellman's method | Electrophorus electricus | 20 | ALA5137046 | single protein format | Scientific Literature | |
2. | ALA5140449 | B | Inhibition of PDE4D7 (unknown origin) | Homo sapiens | 13 | ALA5137046 | single protein format | Scientific Literature | |
3. | ALA5140452 | B | Potency index, ratio of donepezil IC50 to test compound IC50 for inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 10 mins by Ellman's method | Electrophorus electricus | 1 | ALA5137046 | single protein format | Scientific Literature | |
4. | ALA5140453 | B | Inhibition of horse serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 10 mins by Ellman's method | Equus caballus | 6 | ALA5137046 | cell-free format | Scientific Literature | |
5. | ALA5140454 | B | Inhibition of PDE1A (unknown origin) | Homo sapiens | 1 | ALA5137046 | single protein format | Scientific Literature | |
6. | ALA5140455 | B | Inhibition of PDE2A (unknown origin) | Homo sapiens | 1 | ALA5137046 | single protein format | Scientific Literature | |
7. | ALA5140456 | B | Inhibition of PDE3B (unknown origin) | Homo sapiens | 1 | ALA5137046 | single protein format | Scientific Literature | |
8. | ALA5140457 | B | Inhibition of PDE5A (unknown origin) | Homo sapiens | 1 | ALA5137046 | single protein format | Scientific Literature | |
9. | ALA5140458 | B | Inhibition of PDE12C (unknown origin) | Homo sapiens | 1 | ALA5137046 | assay format | Scientific Literature | |
10. | ALA5140459 | B | Inhibition of PDE7A (unknown origin) | Homo sapiens | 1 | ALA5137046 | single protein format | Scientific Literature | |
11. | ALA5140460 | B | Inhibition of PDE8A1 (unknown origin) | Homo sapiens | 1 | ALA5137046 | single protein format | Scientific Literature | |
12. | ALA5140461 | B | Inhibition of PDE9A2 (unknown origin) | Homo sapiens | 1 | ALA5137046 | single protein format | Scientific Literature | |
13. | ALA5140462 | T | Neurotoxicity against rat PC-12 cells assessed as reduction in cell viability up to 20 uM incubated for 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA5137046 | cell-based format | Scientific Literature | |
14. | ALA5140463 | F | Neuroprotective activity against rat PC-12 cells assessed as inhibition of Abeta(25-35)-induced cytotoxicity by measuring increase in cell viability at 10 to 20 uM incubated for 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA5137046 | cell-based format | Scientific Literature | |
15. | ALA5140465 | T | Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability at 20 uM by MTT assay | Mus musculus | 1 | ALA5137046 | cell-based format | Scientific Literature | |
16. | ALA5140466 | F | Anti-neuroinflammatory activity against LPS-stimulated mouse BV-2 cells assessed as reduction in TNF-alpha production pretreated for 1 hr with compound followed by LPS treatment for 24 hrs by ELISA | Mus musculus | 1 | ALA5137046 | cell-based format | Scientific Literature | |
17. | ALA5140467 | F | Anti-neuroinflammatory activity against LPS-stimulated mouse BV-2 cells assessed as reduction in TNF-alpha production at 20 uM pretreated for 1 hr with compound followed by LPS treatment for 24 hrs by ELISA | Mus musculus | 2 | ALA5137046 | cell-based format | Scientific Literature | |
18. | ALA5140468 | F | In vivo inhibition of AChE in hippocampus of aggregated Abeta(25-35)-induced Alzheimer's disease C57BL/6 mouse model at 2 mg/kg, iv measured after 2 hrs by Ellman's method | Mus musculus | 2 | ALA5137046 | organism-based format | Scientific Literature | |
19. | ALA5140469 | F | Anti-neuroinflammatory activity against aggregated Abeta(25-35)-induced Alzheimer's disease C57BL/6 mouse model assessed as inhibition of TNF-alpha production in hippocampus at 2 mg/kg, iv measured after 2 hrs by ELISA | Mus musculus | 2 | ALA5137046 | organism-based format | Scientific Literature |