| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5141671 | B | Binding affinity to N-terminal GST-tagged human NSD2 PWWP1 domain (208 to 369 residues) expressed in Escherichia coli BL2I (DE3) cells assessed as dissociation constant by isothermal titration calorimetry assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA5141681 | B | Protac activity at CRBN E3 ligase/ NSD2 PWWP1 domain (208 to 369 residues) in human KMS-11 cells assessed as induction of NSD2 degradation 2.5 uM incubated for 72 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA5141682 | B | Protac activity at CRBN E3 ligase/ NSD2 PWWP1 domain (208 to 369 residues) in human NCI-H929 cells assessed as induction of NSD2 degradation 2.5 uM incubated for 72 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA5141683 | B | PROTAC activity at CRBN/GSPT1 in human KMS-11 cells assessed as induction of GSPT1 degradation at 2.5 uM incubated for 72 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA5141684 | B | PROTAC activity at CRBN/GSPT1 in human NCI-H929 cells assessed as induction of GSPT1 degradation at 2.5 uM incubated for 72 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA5141685 | B | Protac activity at CRBN/IKZF1 in human KMS-11 cells assessed as induction of IKZF1 degradation at 2.5 uM incubated for 72 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA5141686 | B | Protac activity at CRBN/IKZF1 in human NCI-H929 cells assessed as induction of IKZF1 degradation at 2.5 uM incubated for 72 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA5141687 | B | Protac activity at CRBN/IKZF3 in human KMS-11 cells assessed as induction of IKZF3 degradation at 2.5 uM incubated for 72 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA5141688 | B | Protac activity at CRBN/IKZF3 in human NCI-H929 cells assessed as induction of IKZF3 degradation at 2.5 uM incubated for 72 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature |
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