# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5147366 | B | Inhibition of N-terminal His tagged human EP300 (1159-1666 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay | Homo sapiens | 11 | ALA5143662 | assay format | Scientific Literature | |
2. | ALA5147367 | B | Inhibition of EP300 in human LK2 cells assessed as reduction in intracellular histone H3 acetylation at lysine 27 residue incubated for 3 hrs by chemiluminescence based ELISA | Homo sapiens | 11 | ALA5143662 | cell-based format | Scientific Literature | |
3. | ALA5147368 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining measured after 0.5 hr | Mus musculus | 5 | ALA5143662 | microsome format | Scientific Literature | |
4. | ALA5147369 | F | Inhibition of SOX2 mRNA expression in human LK2 cells incubated for 6 hrs by RT-qPCR analysis | Homo sapiens | 1 | ALA5143662 | cell-based format | Scientific Literature | |
5. | ALA5147370 | P | Solubility of the compound at pH 1.2 | 1 | ALA5143662 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA5147371 | P | Solubility of the compound at pH 6.8 | 1 | ALA5143662 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5147372 | P | Lipophilicity, logD of compound | 1 | ALA5143662 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5147373 | A | Permeability of compound at pH 7.4 by PAMPA assay | 1 | ALA5143662 | assay format | Scientific Literature | ||
9. | ALA5147374 | A | Permeability of compound at pH 5.0 by PAMPA assay | 1 | ALA5143662 | assay format | Scientific Literature | ||
10. | ALA5147375 | A | Protein binding in mouse plasma assessed as unbound fraction | Mus musculus | 1 | ALA5143662 | cell-free format | Scientific Literature | |
11. | ALA5147376 | B | Inhibition of CBP (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay | Homo sapiens | 2 | ALA5143662 | single protein format | Scientific Literature | |
12. | ALA5147377 | B | Inhibition of GST tagged human TIP60 expressed in Sf9 cells using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay | Homo sapiens | 2 | ALA5143662 | cell-based format | Scientific Literature | |
13. | ALA5147378 | B | Inhibition of MYST2 (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay | Homo sapiens | 2 | ALA5143662 | single protein format | Scientific Literature | |
14. | ALA5147379 | B | Inhibition of MYST4 (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay | Homo sapiens | 2 | ALA5143662 | single protein format | Scientific Literature | |
15. | ALA5147380 | B | Inhibition of GST tagged human PCAF (431 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated for 1 hr by AlphaLISA assay | Homo sapiens | 2 | ALA5143662 | cell-based format | Scientific Literature | |
16. | ALA5147381 | B | Inhibition of GST tagged human GCN5 (323 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated for 1 hr by AlphaLISA assay | Homo sapiens | 2 | ALA5143662 | cell-based format | Scientific Literature | |
17. | ALA5147382 | F | Antitumor activity against human LK2 cells xenografted in BALB/c nude mouse assessed as suppression of SOX2 mRNA level in plasma at 50 to 200 mg/kg, po and measured after 6 hrs by qRT-PCR analysis relative to GADPH | Homo sapiens | 1 | ALA5143662 | organism-based format | Scientific Literature | |
18. | ALA5147383 | F | Antitumor activity against human LK2 cells xenografted in BALB/c nude mouse assessed as suppression of SOX2 mRNA level in tumor at 50 to 200 mg/kg, po and measured after 6 hrs by qRT-PCR analysis relative to GADPH | Homo sapiens | 1 | ALA5143662 | organism-based format | Scientific Literature |