# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5141276 | B | Inhibition of GST tagged recombinant human JAK3 expressed in baculovirus infection system by FRET assay | Homo sapiens | 22 | ALA5137068 | assay format | Scientific Literature | |
2. | ALA5141278 | F | Antiproliferative activity against mouse BaF3 parent cell measured after 72 hrs by CCK-8 assay | Mus musculus | 11 | ALA5137068 | cell-based format | Scientific Literature | |
3. | ALA5141279 | F | Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK1 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Mus musculus | 11 | ALA5137068 | cell-based format | Scientific Literature | |
4. | ALA5141280 | F | Antiproliferative activity against mouse BaF3 cells harboring TEL-JAK2 fusion protein assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Mus musculus | 11 | ALA5137068 | cell-based format | Scientific Literature | |
5. | ALA5141281 | F | Antiproliferative activity against mouse BaF3 cells harboring JAK3 M5111 mutant assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Mus musculus | 11 | ALA5137068 | cell-based format | Scientific Literature | |
6. | ALA5141282 | F | Antiproliferative activity against human U-937 cells harboring JAK3 M511135 mutant assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 11 | ALA5137068 | cell-based format | Scientific Literature | |
7. | ALA5141283 | A | Half life in 12 hr fasted SPF Sprague-Dawley rat at 5 mg/kg, iv upon 2 hrs fasting post-administration measured upto 24 hrs | Rattus norvegicus | 2 | ALA5137068 | organism-based format | Scientific Literature | |
8. | ALA5141284 | A | Half life in 12 hr fasted SPF Sprague-Dawley rat at 15 mg/kg, po upon 2 hrs fasting post-administration measured upto 24 hrs | Rattus norvegicus | 2 | ALA5137068 | organism-based format | Scientific Literature | |
9. | ALA5141285 | A | Cmax in 12 hr fasted SPF Sprague-Dawley rat at 5 mg/kg, iv upon 2 hrs fasting post-administration measured upto 24 hrs | Rattus norvegicus | 2 | ALA5137068 | organism-based format | Scientific Literature | |
10. | ALA5141286 | A | Cmax in 12 hr fasted SPF Sprague-Dawley rat at 15 mg/kg, po upon 2 hrs fasting post-administration measured upto 24 hrs | Rattus norvegicus | 2 | ALA5137068 | organism-based format | Scientific Literature | |
11. | ALA5141287 | A | AUC(0 to infinity) in 12 hr fasted SPF Sprague-Dawley rat at 15 mg/kg, po upon 2 hrs fasting post-administration upto 24 hrs | Rattus norvegicus | 2 | ALA5137068 | organism-based format | Scientific Literature | |
12. | ALA5141288 | A | AUC(0 to infinity) in 12 hr fasted SPF Sprague-Dawley rat at 5 mg/kg, iv upon 2 hrs fasting post-administration measured upto 24 hrs | Rattus norvegicus | 2 | ALA5137068 | organism-based format | Scientific Literature | |
13. | ALA5141289 | A | Clearance in 12 hr fasted SPF Sprague-Dawley rat at 5 mg/kg, iv upon 2 hrs fasting post-administration measured upto 24 hrs | Rattus norvegicus | 2 | ALA5137068 | organism-based format | Scientific Literature | |
14. | ALA5141290 | A | Oral bioavailability in 12 hr fasted SPF Sprague-Dawley rat at 15 mg/kg upon 2 hrs fasting post-administration measured upto 24 hrs | Rattus norvegicus | 2 | ALA5137068 | organism-based format | Scientific Literature | |
15. | ALA5141291 | B | Inhibition of human ARK5 at 0.5 uM relative to control | Homo sapiens | 1 | ALA5137068 | single protein format | Scientific Literature | |
16. | ALA5141292 | B | Inhibition of human CDK16/cyclin-Y at 0.5 uM relative to control | Homo sapiens | 1 | ALA5137068 | protein complex format | Scientific Literature | |
17. | ALA5141293 | B | Inhibition of human FLT3 at 0.5 uM relative to control | Homo sapiens | 1 | ALA5137068 | single protein format | Scientific Literature | |
18. | ALA5141294 | B | Inhibition of human JAK1 at 0.5 uM relative to control | Homo sapiens | 1 | ALA5137068 | single protein format | Scientific Literature | |
19. | ALA5141295 | B | Inhibition of human JAK2 at 0.5 uM relative to control | Homo sapiens | 1 | ALA5137068 | single protein format | Scientific Literature | |
20. | ALA5141296 | B | Inhibition of human JAK3 at 0.5 uM relative to control | Homo sapiens | 1 | ALA5137068 | single protein format | Scientific Literature |