| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5151316 | B | Binding affinity to recombinant WDR5 (unknown origin) expressed in Escherichia coli BL21 assessed as shift in melting temperature by DSF assay | Homo sapiens | 28 | assay format | Scientific Literature | ||
| 2. | ALA5151317 | B | Binding affinity to recombinant WDR5 (unknown origin) expressed in Escherichia coli BL21 assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 28 | assay format | Scientific Literature | ||
| 3. | ALA5151318 | B | Displacement of N-(4'-((17-(5,5-difluoro-7-(1H-pyrrol-2-yl)-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-15-oxo-4,7,10-trioxa-14-azaheptadecyl)carbamoyl)-4-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-3-yl)-6-hydroxy-4-(trifluoromethyl)nicotinamide tracer from N-/C-terminal NanoLuc-fused full-length WDR5 (unknown origin) transfected in HEK293T cells incubated for 2 hrs by NanoBRET assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 4. | ALA5151319 | B | Displacement of N-(4'-((17-(5,5-difluoro-7-(1H-pyrrol-2-yl)-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-15-oxo-4,7,10-trioxa-14-azaheptadecyl)carbamoyl)-4-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-3-yl)-6-hydroxy-4-(trifluoromethyl)nicotinamide tracer from N-/C-terminal NanoLuc-fused full-length WDR5 (unknown origin) transfected in HEK293T cell lysate incubated for 2 hrs by NanoBRET assay | Homo sapiens | 28 | subcellular format | Scientific Literature | ||
| 5. | ALA5151320 | B | Binding affinity to recombinant WDR5 (unknown origin) expressed in Escherichia coli BL21 assessed as change in enthalpy by isothermal titration calorimetry | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 6. | ALA5151321 | B | Binding affinity to recombinant WDR5 (unknown origin) expressed in Escherichia coli BL21 assessed as change in entropy by isothermal titration calorimetry | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 7. | ALA5151322 | B | PROTAC activity at VHL/HiBit-tagged WDR5 in human MV4-11 cells assessed as induction of WDR5 degradation incubated for 6 to 24 hrs by HiBiT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 8. | ALA5151323 | B | PROTAC activity at VHL/HiBit-tagged WDR5 in human MV4-11 cells assessed as maximum degradation of WDR5 incubated for 6 to 24 hrs by HiBiT assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 9. | ALA5151324 | B | PROTAC activity at VHL/HiBit-tagged WDR5 in human MV4-11 cells assessed as maximum degradation of WDR5 incubated for 6 to 24 hrs by HiBiT assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 10. | ALA5151325 | B | PROTAC activity at VHL/HiBit-tagged WDR5 in human MV4-11 cells assessed as induction of WDR5 degradation incubated for 24 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA5151326 | B | PROTAC activity at VHL/WDR5 in human MV4-11 cells assessed as induction of WDR5 degradation incubated for 72 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA5151328 | B | PROTAC activity at VHL/WDR5 in human MV4-11 cells assessed as reduction in protein stability at 3 uM incubated upto 12 hrs in presence of cycloheximide by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5151330 | B | PROTAC activity at VHL/WDR5 in human MV4-11 cells assessed as decrease in mRNA level at 3 uM incubated for 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5151332 | B | PROTAC activity at VHL/WDR5 in human MV4-11 cells assessed as induction of WDR5 degradation at 3 uM incubated for 6 hrs in presence of MG132 by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5151333 | B | PROTAC activity at VHL/WDR5 in human MV4-11 cells assessed as induction of WDR5 degradation at 3 uM incubated for 6 hrs in presence of MLN4924 by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5151335 | B | PROTAC activity at VHL/WDR5 in human MV4-11 cells assessed as induction of WDR5 degradation at 1 uM incubated for 9 hrs by mass spectrometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA5151336 | B | PROTAC activity at VHL/WDR5 in human MV4-11 cells assessed as induction of WDR5 degradation at 5 uM incubated for 9 hrs by mass spectrometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA5151339 | F | Cytotoxicity against human MV4-11 cells assessed as defect in cell proliferation at 10 uM incubated for 15 days with replacement of fresh medium containing compound on every third day | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5151340 | F | Cytotoxicity against human MV4-11 cells assessed as defect in cell proliferation at 3 to 5 uM incubated for 15 days with replacement of fresh medium containing compound on every third day | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5151342 | B | PROTAC activity at VHL/HiBit-tagged WDR5 in human MV4-11 cells assessed as induction of WDR5 degradation incubated for 24 hrs by HiBiT assay | Homo sapiens | 2 | cell-based format | Scientific Literature |
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