| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5167322 | B | Displacement of [3H]Ro151788 from human recombinant alpha5beta3gamma2 GABAA receptor stably expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay | Homo sapiens | 38 | cell membrane format | Scientific Literature | ||
| 2. | ALA5167323 | B | Negative allosteric modulation activity at human recombinant alpha5beta3gamma2 GABAA receptor stably expressed in HEK293 cells assessed as modulation at alpha5 subunit at 1 uM by Patch clamp method | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 3. | ALA5167324 | B | Negative allosteric modulation activity at human recombinant alpha5beta3gamma2 GABAA receptor stably expressed in HEK293 cells assessed as modulation at alpha5 subunit at 10 uM by Patch clamp method | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 4. | ALA5167325 | B | Negative allosteric modulation activity at human recombinant alpha1beta3gamma2 GABAA receptor stably expressed in HEK293 cells assessed as modulation at alpha1 subunit at 10 uM by Patch clamp method | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 5. | ALA5167326 | T | Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp method | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 6. | ALA5167327 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 2.5 uM | Homo sapiens | 38 | microsome format | Scientific Literature | ||
| 7. | ALA5167328 | A | Metabolic stability in Wistar rat liver microsomes assessed as intrinsic clearance at 2.5 uM | Rattus norvegicus | 38 | microsome format | Scientific Literature |
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