# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5141994 | Binding | Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assay | Homo sapiens | 29 | ALA5137081 | assay format | Scientific Literature | |
2. | ALA5141995 | Functional | Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by CellTiter-Glo assay | Homo sapiens | 27 | ALA5137081 | cell-based format | Scientific Literature | |
3. | ALA5141996 | Physicochemical | Solubility of compound at pH 7 by HPLC analysis | 14 | ALA5137081 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5141997 | ADME | Metabolic stability in human liver microsome assessed as intrinsic clearance pretreated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Homo sapiens | 18 | ALA5137081 | microsome format | Scientific Literature | |
5. | ALA5141998 | ADME | Apparent permeability across apical to basolateral side in dog MDCK-MDR1 cells in presence of p-gp inhibitor | Canis lupus familiaris | 11 | ALA5137081 | cell-based format | Scientific Literature | |
6. | ALA5141999 | ADME | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in dog MDCK-MDR1 cells | Canis lupus familiaris | 5 | ALA5137081 | cell-based format | Scientific Literature | |
7. | ALA5142000 | Binding | Binding affinity to His fused human DHODH expressed in Escherichia coli by surface plasmon resonance assay | Homo sapiens | 2 | ALA5137081 | assay format | Scientific Literature | |
8. | ALA5142001 | Binding | Binding affinity to His fused human DHODH expressed in Escherichia coli assessed as dissociation half life by surface plasmon resonance assay | Homo sapiens | 2 | ALA5137081 | assay format | Scientific Literature | |
9. | ALA5142002 | Functional | Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs | Homo sapiens | 2 | ALA5137081 | cell-based format | Scientific Literature | |
10. | ALA5142003 | Binding | Inhibition of mouse DHODH | Mus musculus | 2 | ALA5137081 | single protein format | Scientific Literature | |
11. | ALA5142004 | Binding | Inhibition of rat DHODH | Rattus norvegicus | 2 | ALA5137081 | single protein format | Scientific Literature | |
12. | ALA5142005 | Binding | Inhibition of dog DHODH | Canis lupus familiaris | 2 | ALA5137081 | assay format | Scientific Literature | |
13. | ALA5142006 | Binding | Inhibition of monkey DHODH | Macaca mulatta | 2 | ALA5137081 | assay format | Scientific Literature | |
14. | ALA5142007 | ADME | Metabolic stability in mouse liver microsome assessed as intrinsic clearance pretreated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Mus musculus | 2 | ALA5137081 | microsome format | Scientific Literature | |
15. | ALA5142008 | ADME | Metabolic stability in rat liver microsome assessed as intrinsic clearance pretreated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Rattus norvegicus | 2 | ALA5137081 | microsome format | Scientific Literature | |
16. | ALA5142009 | ADME | Metabolic stability in dog liver microsome assessed as intrinsic clearance pretreated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Canis lupus familiaris | 2 | ALA5137081 | microsome format | Scientific Literature | |
17. | ALA5142010 | ADME | Metabolic stability in monkey liver microsome assessed as intrinsic clearance pretreated for 5 mins followed by NADPH addition and measured upto 60 mins by HPLC-MS/MS analysis | Macaca mulatta | 2 | ALA5137081 | microsome format | Scientific Literature | |
18. | ALA5142011 | ADME | Intrinsic clearance in mouse hepatocytes measured per 10^6 cells | Mus musculus | 2 | ALA5137081 | cell-based format | Scientific Literature | |
19. | ALA5142012 | ADME | Stability in human hepatocytes assessed as intrinsic clearance measured per 10^6 cells incubated upto 120 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA5137081 | cell-based format | Scientific Literature | |
20. | ALA5142013 | ADME | Intrinsic clearance in rat hepatocytes measured per 10^6 cells | Rattus norvegicus | 2 | ALA5137081 | cell-based format | Scientific Literature |