| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5149726 | B | Inhibition of human NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ethyl isopropyl amiloride by BCECF-AM dye based fluorescence assay | Homo sapiens | 46 | cell-based format | Scientific Literature | ||
| 2. | ALA5149727 | B | Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ethyl isopropyl amiloride by BCECF-AM dye based fluorescence assay | Rattus norvegicus | 43 | cell-based format | Scientific Literature | ||
| 3. | ALA5149728 | A | Cmax in Sprague-Dawley rat at 11 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 4. | ALA5149729 | A | Dose normalized AUC in Sprague-Dawley rat at 11 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 5. | ALA5149743 | F | In vivo inhibition of NEH3 in Sprague-Dawley rat assessed as fecal form score at 3 mg/kg, po administered via gavage measured after 6 hrs | Rattus norvegicus | 30 | organism-based format | Scientific Literature | ||
| 6. | ALA5149744 | F | In vivo inhibition of NEH3 in Sprague-Dawley rat assessed as fecal water content at 3 mg/kg, po administered via gavage measured after 6 hrs | Rattus norvegicus | 30 | organism-based format | Scientific Literature | ||
| 7. | ALA5149745 | F | In vivo inhibition of NEH3 in Sprague-Dawley rat assessed as sodium excretion in urine at 10 mg/kg, po administered via gavage measured after 6 hrs by ion chromatography relative to control | Rattus norvegicus | 30 | organism-based format | Scientific Literature |
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