# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5135712 | Functional | Induction of apoptosis in human AN3-CA cells assessed as increase in cleaved caspase-3 expression at 0.1 uM incubated for 24 to 48 hrs by immunoblotting analysis | Homo sapiens | 3 | ALA5131515 | cell-based format | Scientific Literature | |
2. | ALA5135713 | Binding | Inhibition of FGFR2 K310R/N549K mutant in human AN3-CA cells assessed as inhibition of FGFalpha-stimulated PLCgamma phosphorylation at Tyr783 residue pretreated for 2 hrs followed by incubation with FGFalpha/heparin sulfate for 20 mins by western blot analysis | Homo sapiens | 3 | ALA5131515 | cell-based format | Scientific Literature | |
3. | ALA5135714 | Binding | Inhibition of TEL-V555M-FGFR3 mutant (unknown origin) transformed in serum starved mouse BaF3 cells assessed as inhibition of FGFalpha-stimulated FGFR3 phosphorylation at Tyr653/654 residues at 1 to 5 uM pretreated for 2 hrs followed by incubation with FGFalpha/heparin sulfate for 20 mins by western blot analysis | Homo sapiens | 3 | ALA5131515 | cell-based format | Scientific Literature | |
4. | ALA5135715 | Binding | Inhibition of TEL-FGFR3 (unknown origin) transformed in serum starved mouse BaF3 cells assessed as inhibition of FGFalpha-stimulated FGFR3 phosphorylation at Tyr653/654 residues at 1 to 5 uM pretreated for 2 hrs followed by incubation with FGFalpha/heparin sulfate for 20 mins by western blot analysis | Homo sapiens | 3 | ALA5131515 | cell-based format | Scientific Literature | |
5. | ALA5135717 | Binding | Inhibition of wild-type FGFR1 (unknown origin) by radiometric kinase activity assay | Homo sapiens | 9 | ALA5131515 | single protein format | Scientific Literature | |
6. | ALA5135718 | Binding | Inhibition of wild-type FGFR2 (unknown origin) by radiometric kinase activity assay | Homo sapiens | 9 | ALA5131515 | single protein format | Scientific Literature | |
7. | ALA5135719 | Binding | Inhibition of wild-type FGFR3 (unknown origin) by radiometric kinase activity assay | Homo sapiens | 27 | ALA5131515 | single protein format | Scientific Literature | |
8. | ALA5135720 | Binding | Inhibition of wild-type FGFR4 (unknown origin) by radiometric kinase activity assay | Homo sapiens | 9 | ALA5131515 | single protein format | Scientific Literature | |
9. | ALA5135721 | Binding | Inhibition of FGFR1 V561M mutant (unknown origin) by radiometric kinase activity assay | Homo sapiens | 9 | ALA5131515 | single protein format | Scientific Literature | |
10. | ALA5135722 | Binding | Inhibition of FGFR2 V564F mutant (unknown origin) by radiometric kinase activity assay | Homo sapiens | 15 | ALA5131515 | assay format | Scientific Literature | |
11. | ALA5135723 | Binding | Inhibition of FGFR3 V555M mutant (unknown origin) by radiometric kinase activity assay | Homo sapiens | 17 | ALA5131515 | single protein format | Scientific Literature | |
12. | ALA5135724 | Binding | Inhibition of FGFR2 N549H mutant (unknown origin) by radiometric kinase activity assay | Homo sapiens | 24 | ALA5131515 | single protein format | Scientific Literature | |
13. | ALA5135725 | Binding | Inhibition of FGFR3 K650E mutant (unknown origin) by radiometric kinase activity assay | Homo sapiens | 9 | ALA5131515 | single protein format | Scientific Literature | |
14. | ALA5135726 | Binding | Inhibition of FGFR3 K650M mutant (unknown origin) by radiometric kinase activity assay | Homo sapiens | 9 | ALA5131515 | single protein format | Scientific Literature | |
15. | ALA5135730 | Functional | Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR3-V555M mutant assessed as cell growth inhibition by CellTiter-Glo assay | Mus musculus | 27 | ALA5131515 | cell-based format | Scientific Literature | |
16. | ALA5135731 | Functional | Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR3 assessed as cell growth inhibition by CellTiter-Glo assay | Mus musculus | 27 | ALA5131515 | cell-based format | Scientific Literature | |
17. | ALA5135732 | Toxicity | Antiproliferative activity against mouse BaF3 cells assessed as cell growth inhibition by CellTiter-Glo assay | Mus musculus | 27 | ALA5131515 | cell-based format | Scientific Literature | |
18. | ALA5135733 | Functional | Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR4 V550E mutant assessed as cell growth inhibition by CellTiter-Glo assay | Mus musculus | 9 | ALA5131515 | cell-based format | Scientific Literature | |
19. | ALA5135734 | Functional | Antiproliferative activity against mouse BaF3 cells harboring TEL-FGFR4 N535K mutant assessed as cell growth inhibition by CellTiter-Glo assay | Mus musculus | 9 | ALA5131515 | cell-based format | Scientific Literature | |
20. | ALA5135735 | Functional | Antiproliferative activity against human AN3-CA cells harboring FGFR2 K310R/N549K mutant assessed as cell growth inhibition by CellTiter-Glo assay | Homo sapiens | 27 | ALA5131515 | cell-based format | Scientific Literature |