# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5123995 | F | Antileishmanial activity against intracellular Leishmania infantum MHOM/MA(BE)/67 ITMAP263 amastigotes infected in Swiss mouse peritoneal macrophage assessed as inhibition of parasite growth measured after 5 days by geimsa staining based microscopic analysis | Leishmania infantum | 46 | ALA5120865 | organism-based format | Scientific Literature | |
2. | ALA5123996 | T | Cytotoxicity against Swiss mouse peritoneal macrophages assessed as reduction in cell viability measured after 5 days by microscopic analysis | Mus musculus | 46 | ALA5120865 | cell-based format | Scientific Literature | |
3. | ALA5123997 | T | Selectivity index, ratio of CC50 for Cytotoxicity against Swiss mouse peritoneal macrophages to EC50 for intracellular Leishmania infantum MHOM/MA(BE)/67 ITMAP263 amastigotes infected in Swiss mouse peritoneal macrophages | 45 | ALA5120865 | cell-based format | Scientific Literature | ||
4. | ALA5123998 | T | Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 3 days by resazurin dye based fluorescence analysis | Homo sapiens | 39 | ALA5120865 | cell-based format | Scientific Literature | |
5. | ALA5123999 | F | Antileishmanial activity against sodium stibogluconate and potassium antimonyl tartrate resistant intracellular Leishmania infantum MHOM/FR/96/LEM3323-CI4 promastigotes infected in Swiss mouse peritoneal macrophages assessed as inhibition of parasite growth measured after 96 hrs by microscopic analysis | Leishmania infantum | 2 | ALA5120865 | organism-based format | Scientific Literature | |
6. | ALA5124000 | F | Antileishmanial activity against sodium stibogluconate, potassium antimonyl tartrate and MIL resistant intracellular Leishmania infantum MHOM/FR/96/LEM3323-CI4 MIL5C13 promastigotes infected in Swiss mouse peritoneal macrophages assessed as inhibition of parasite growth measured after 96 hrs by microscopic analysis | Leishmania infantum | 2 | ALA5120865 | organism-based format | Scientific Literature | |
7. | ALA5124001 | F | Antileishmanial activity against sodium stibogluconate, potassium antimonyl tartrate and PMM resistant intracellular Leishmania infantum MHOM/FR/96/LEM3323-CI4 PMM promastigotes infected in Swiss mouse peritoneal macrophages assessed as inhibition of parasite growth measured after 96 hrs by microscopic analysis | Leishmania infantum | 2 | ALA5120865 | organism-based format | Scientific Literature | |
8. | ALA5124002 | F | Antitrypanosomal activity against nifurtimox-sensitive Tulahuen CL2 amastigotes expressing beta galactosidase infected in human MRC5 cells assessed as inhibition of parasite growth using chlorophenol red beta-D-galactopyranoside as substrate and measured after 7 days by spectrophotometric analysis | Trypanosoma cruzi | 12 | ALA5120865 | organism-based format | Scientific Literature | |
9. | ALA5124003 | A | Metabolic stability in golden hamster liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 60 mins in presence of NADPH | Mesocricetus auratus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
10. | ALA5124004 | A | Metabolic stability in golden hamster liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 30 mins in presence of NADPH | Mesocricetus auratus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
11. | ALA5124005 | A | Metabolic stability in golden hamster liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 15 mins in presence of NADPH | Mesocricetus auratus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
12. | ALA5124006 | A | Metabolic stability in mouse liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 60 mins in presence of NADPH | Mus musculus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
13. | ALA5124007 | A | Metabolic stability in mouse liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 30 mins in presence of NADPH | Mus musculus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
14. | ALA5124008 | A | Metabolic stability in mouse liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 60 mins in presence of NADPH | Mus musculus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
15. | ALA5124009 | A | Metabolic stability in mouse liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 30 mins in presence of NADPH | Mus musculus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
16. | ALA5124010 | A | Metabolic stability in mouse liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 15 mins in presence of NADPH | Mus musculus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
17. | ALA5124011 | T | Selectivity index, ratio of CC50 for cytotoxicity against human MRC5 cells to EC50 for Trypanosoma cruzi Tulahuen CL2 amastigotes expressing beta galactosidase infected in human MRC5 cells | 12 | ALA5120865 | cell-based format | Scientific Literature | ||
18. | ALA5124012 | A | Metabolic stability in mouse liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 15 mins in presence of NADPH | Mus musculus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
19. | ALA5124014 | A | Metabolic stability in golden hamster liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 15 mins in presence of NADPH | Mesocricetus auratus | 2 | ALA5120865 | subcellular format | Scientific Literature | |
20. | ALA5124015 | A | Metabolic stability in golden hamster liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 30 mins in presence of NADPH | Mesocricetus auratus | 2 | ALA5120865 | subcellular format | Scientific Literature |