# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5157612 | T | Cytotoxicity against human TZM-bl cells harboring beta-galactosidase/luciferase reporter gene assessed as cell viability at 100 nM measured after 48 hrs by MTT assay relative to control | Homo sapiens | 6 | ALA5154697 | cell-based format | Scientific Literature | |
2. | ALA5157613 | F | Antiviral activity against HIV1 NL4.3 infected in human TZM-bl cells assessed as inhibition of viral infection at 100 nM measured after 48 hrs by steady-glo luciferase reporter gene assay relative to control | Human immunodeficiency virus 1 | 6 | ALA5154697 | organism-based format | Scientific Literature | |
3. | ALA5157614 | T | Cytotoxicity against human CEM-GFP cells assessed as cell viability at 100 nM measured after 48 hrs by MTT assay relative to control | Homo sapiens | 6 | ALA5154697 | cell-based format | Scientific Literature | |
4. | ALA5157615 | F | Antiviral activity against HIV1 NL4.3 virus infected in human CEM-GFP cells assessed as reduction in p24 antigen level at 100 nM measured after 72 hrs by ELISA relative to control | Human immunodeficiency virus 1 | 6 | ALA5154697 | organism-based format | Scientific Literature | |
5. | ALA5157616 | T | Cytotoxicity against human CEM-GFP cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 2 | ALA5154697 | cell-based format | Scientific Literature | |
6. | ALA5157617 | F | Antiviral activity against HIV1 NL4.3 virus infected in human CEM-GFP cells assessed as reduction in p24 antigen level measured after 72 hrs by ELISA | Human immunodeficiency virus 1 | 2 | ALA5154697 | organism-based format | Scientific Literature | |
7. | ALA5157618 | T | Therapeutic index, ratio of CC50 for cytotoxicity against human CEM-GFP cells to IC50 for antiviral activity against HIV1 NL4.3 virus infected in human CEM-GFP cells assessed as reduction in p24 antigen level | 2 | ALA5154697 | cell-based format | Scientific Literature | ||
8. | ALA5157619 | B | Inhibition of full-length recombinant HIV1 integrase at 100 nM using target substrate DNA preincubated for 5 mins followed by substrate addition and measured after 30 mins by colorimetry relative to control | Human immunodeficiency virus 1 | 1 | ALA5154697 | single protein format | Scientific Literature | |
9. | ALA5157620 | B | Inhibition of HIV-1 protease at 100 nM using fluorophore-labelled peptide substrate by fluorescence assay relative to control | Human immunodeficiency virus 1 | 1 | ALA5154697 | single protein format | Scientific Literature | |
10. | ALA5157621 | B | Inhibition of HIV-1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as reduction in biotin-dUTP incorporation at 100 nM using poly(A)/oligo (dT)15 as template/primer by ELISA relative to control | Human immunodeficiency virus 1 | 1 | ALA5154697 | single protein format | Scientific Literature |