# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5146944 | Binding | Covalent inhibition of recombinant recombinant human GST-tagged JAK3(781 to 1124 residues) expressed in baculovirus expression system incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assay | Homo sapiens | 21 | ALA5143636 | assay format | Scientific Literature | |
2. | ALA5146945 | Binding | Inhibition of JAK1 (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assay | Homo sapiens | 1 | ALA5143636 | single protein format | Scientific Literature | |
3. | ALA5146946 | Binding | Inhibition of JAK2 (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assay | Homo sapiens | 1 | ALA5143636 | single protein format | Scientific Literature | |
4. | ALA5146947 | Binding | Inhibition of TYK2 (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assay | Homo sapiens | 1 | ALA5143636 | single protein format | Scientific Literature | |
5. | ALA5146948 | Binding | Inhibition of BTK (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assay | Homo sapiens | 1 | ALA5143636 | single protein format | Scientific Literature | |
6. | ALA5146949 | Binding | Inhibition of wild type EGFR (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assay | Homo sapiens | 1 | ALA5143636 | single protein format | Scientific Literature | |
7. | ALA5146950 | Binding | Inhibition of EGFR T790M mutant (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assay | Homo sapiens | 1 | ALA5143636 | single protein format | Scientific Literature | |
8. | ALA5146951 | Binding | Selectivity ratio of IC50 for inhibition of BTK (unknown origin) to IC50 for covalent inhibition of recombinant human GST-tagged JAK3 (781 to 1124 residues) expressed in baculovirus expression system | 1 | ALA5143636 | assay format | Scientific Literature | ||
9. | ALA5146952 | Binding | Selectivity ratio of IC50 for inhibition of wild type EGFR (unknown origin) to IC50 for covalent inhibition of recombinant human GST-tagged JAK3 (781 to 1124 residues) expressed in baculovirus expression system | 1 | ALA5143636 | assay format | Scientific Literature | ||
10. | ALA5146953 | Binding | Selectivity ratio of IC50 for inhibition of EGFR T790M mutant (unknown origin) to IC50 for covalent inhibition of recombinant human GST-tagged JAK3 (781 to 1124 residues) expressed in baculovirus expression system | 1 | ALA5143636 | assay format | Scientific Literature | ||
11. | ALA5146954 | Functional | Antiproliferative activity against human U-937 cells harbouring JAK3 M511 mutation assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 12 | ALA5143636 | cell-based format | Scientific Literature | |
12. | ALA5146955 | Functional | Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5143636 | cell-based format | Scientific Literature | |
13. | ALA5146956 | Functional | Antiproliferative activity against human COLO 205 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5143636 | cell-based format | Scientific Literature | |
14. | ALA5146957 | Functional | Antiproliferative activity against human OCILY3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5143636 | cell-based format | Scientific Literature | |
15. | ALA5146958 | Functional | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5143636 | cell-based format | Scientific Literature | |
16. | ALA5146959 | Functional | Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5143636 | cell-based format | Scientific Literature | |
17. | ALA5146960 | Functional | Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5143636 | cell-based format | Scientific Literature | |
18. | ALA5146961 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5143636 | cell-based format | Scientific Literature | |
19. | ALA5146962 | Functional | Antiproliferative activity against human Daudi cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5143636 | cell-based format | Scientific Literature | |
20. | ALA5146963 | Binding | Inhibition of JAK3 phosphorylation in human U-937 cells measured after 12 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5143636 | cell-based format | Scientific Literature |