| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5162393 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as effect on liver CPT1a mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5162394 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in HMGCS2 mRNA levels at 100 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA5162395 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in liver CPT1a mRNA levels at 100 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5162396 | B | Agonist activity at yeast Gal4-fused human PPARalpha LBD transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase activity incubated for 20 hrs by luminometry | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 5. | ALA5162397 | B | Agonist activity at yeast Gal4-fused human PPARalpha LBD transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase activity incubated for 20 hrs by luminometry relative to control | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 6. | ALA5162398 | B | Agonist activity at yeast Gal4-fused human PPARgamma transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase activity incubated for 20 hrs by luminometry | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 7. | ALA5162399 | B | Agonist activity at yeast Gal4-fused human PPARgamma transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase activity incubated for 20 hrs by luminometry relative to control | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 8. | ALA5162400 | B | Agonist activity at yeast Gal4-fused human PPARdelta transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase activity incubated for 20 hrs by luminometry | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 9. | ALA5162401 | B | Agonist activity at yeast Gal4-fused human PPARdelta transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase activity incubated for 20 hrs by luminometry relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA5162402 | F | Reduction of lipid accumulation in oleic acid-induced steatosis in human HepaRG cells at 100 uM treated for 24 hrs by spectrophotometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5162403 | F | Reduction of lipid accumulation in oleic acid-induced steatosis in human HepaRG cells at 100 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by Oil Red O staining based microscopy | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5162404 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in HMGCS2 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5162405 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in FGF21 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5162406 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in PDK4 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5162407 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in FABP1 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5162408 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as effect on ABCA1 mRNA levels at 100 uM treated for 24 hrs by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5162409 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in FGF21 mRNA levels at 100 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5162410 | B | Agonist activity at PPAR in oleic acid-induced steatosis in human HepaRG cells assessed as increase in FABP1 mRNA levels at 100 uM treated for 2 weeks with media replenishment along with compound and inducer for every 2 days by RT-qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5162412 | F | Induction of 2-NBD-glucose uptake in mouse C2C12 cells at 25 uM incubated in starvation medium with replacement of fresh medium for every 24 hrs for 96 hrs followed by insulin stimulation for 30 mins followed by 2-NBD-glucose treatment for 3 hrs by flow cytometric analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5162413 | F | Induction of glucose uptake in mouse C2C12 cells assessed as increase in GLUT4 expression at 25 uM incubated in starvation medium with replacement of fresh medium for every 24 hrs for 96 hrs by Western blotting analysis | Mus musculus | 1 | cell-based format | Scientific Literature |
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