# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5159111 | A | Drug localization in nucleus of human HT-29 cells at 25 uM incubated for 30 to 120 mins by DAPI staining based fluorescence microscopic analysis | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
2. | ALA5159112 | A | Drug localization in nucleus of Trypanosoma brucei at 5 uM incubated for 30 to 120 mins by DAPI staining based fluorescence microscopic analysis | Trypanosoma brucei | 2 | subcellular format | Scientific Literature | ||
3. | ALA5159113 | F | Antitrypanosomal activity against Trypanosoma brucei incubated for 72 hrs by alamar blue dye based fluorimetry analysis | Trypanosoma brucei | 16 | organism-based format | Scientific Literature | ||
4. | ALA5159114 | F | Antileishmanial activity against Leishmania major (MHOM/IL/80/Friedlin) promastigotes assessed as reduction in parasite growth incubated for 72 hrs by MTT assay | Leishmania major | 16 | organism-based format | Scientific Literature | ||
5. | ALA5159115 | F | Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
6. | ALA5159116 | T | Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
7. | ALA5159117 | T | Selectivity index, ratio of IC50 for human MRC5 cells to IC50 for human HT-29 cells | 16 | assay format | Scientific Literature | |||
8. | ALA5159118 | T | Selectivity index, ratio of IC50 for cytotoxicity against human MRC5 cells to IC50 for antileishmanial activity against Leishmania major (MHOM/IL/80/Friedlin) promastigotes | 13 | cell-based format | Scientific Literature | |||
9. | ALA5159119 | T | Selectivity index, ratio of IC50 for cytotoxicity against human MRC5 cells to IC50 for antitrypanosomal activity against Trypanosoma brucei | 16 | cell-based format | Scientific Literature | |||
10. | ALA5159120 | B | Binding affinity to human G-quadruplex telomeric DNA F21T (5'-duplex GGG TTAGGG TTAGGG TTAGGG-3') assessed as change in melting temperature at 1 uM incubated for 5 min by FRET assay | Homo sapiens | 6 | nucleic acid format | Scientific Literature | ||
11. | ALA5159121 | B | Binding affinity to parallel G-quadruplex DNA TGGGGT TGGGGT TGGGGT TGGGGT (unknown origin) by mass spectrometric analysis | Not specified | 4 | nucleic acid format | Scientific Literature | ||
12. | ALA5159122 | B | Binding affinity to human G-quadruplex telomeric DNA F21T (5'-duplex GGG TTAGGG TTAGGG TTAGGG-3') by mass spectrometric analysis | Homo sapiens | 4 | nucleic acid format | Scientific Literature | ||
13. | ALA5159123 | A | Drug uptake in human HT-29 cells at 10 uM incubated for 2 hrs by fluorescence based multiplate reader method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
14. | ALA5159124 | A | Drug uptake in human MRC5 cells at 10 uM incubated for 2 hrs by fluorescence based multiplate reader method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
15. | ALA5159125 | A | Drug uptake in Trypanosoma brucei at 10 uM incubated for 2 hrs by fluorescence based multiplate reader method | Trypanosoma brucei | 10 | assay format | Scientific Literature | ||
16. | ALA5159126 | A | Drug localization in cytoplasm of Trypanosoma brucei at 5 uM incubated for 30 to 120 mins by DAPI staining based fluorescence microscopic analysis | Trypanosoma brucei | 2 | subcellular format | Scientific Literature | ||
17. | ALA5159127 | B | Binding affinity to G-quadruplex DNA TGGGGT TGGGGT TGGGGT TGGGGT (unknown origin) assessed as equilibrium binding constant | Not specified | 4 | nucleic acid format | Scientific Literature |