# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5167217 | B | Activation of Nrf2 transcriptional activity in mouse Hepa1c1c7 cells assessed as increase in NQO1 activity at 100 uM measured after 24 hrs relative to control | Mus musculus | 2 | ALA5154913 | cell-based format | Scientific Literature | |
2. | ALA5167218 | B | Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction expressed in Escherichia coli BL21 codon plus cells using FITC-beta-DEETGEF-OH as substrate incubated for 30 mins by fluorescence polarization assay | Homo sapiens | 18 | ALA5154913 | cell-based format | Scientific Literature | |
3. | ALA5167219 | B | Binding affinity to Keap1 kelch domain (unknown origin) expressed in Escherichia coli BL21 codon plus cells assessed as inflection temperature at 10 uM incubated for 30 mins by differential scanning fluorimetry (Rvb = 61.3 +/- 0.1 degreeC) | Homo sapiens | 16 | ALA5154913 | cell-based format | Scientific Literature | |
4. | ALA5167220 | B | Binding affinity to Keap1 (unknown origin) expressed in Escherichia coli BL21 codon plus cells by isothermal titration calorimetry | Homo sapiens | 6 | ALA5154913 | cell-based format | Scientific Literature | |
5. | ALA5167221 | B | Activation of Nrf2 transcriptional activity in mouse Hepa1c1c7 cells assessed as fold induction in NQO1 activity at 10 uM after 24 hrs | Mus musculus | 15 | ALA5154913 | cell-based format | Scientific Literature | |
6. | ALA5167222 | B | Activation of Nrf2 transcriptional activity in mouse Hepa1c1c7 cells assessed as increase in NQO1 activity measured after 24 hrs | Mus musculus | 6 | ALA5154913 | cell-based format | Scientific Literature | |
7. | ALA5167231 | P | Chromatographic hydrophobicity index, log D of the compound at pH 2.0 by HPLC analysis | 2 | ALA5154913 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5167232 | P | Chromatographic hydrophobicity index, log D of the compound at pH 7.4 by HPLC analysis | 2 | ALA5154913 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA5167233 | P | Chromatographic hydrophobicity index, log D of the compound at pH 10.5 by HPLC analysis | 2 | ALA5154913 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA5167234 | A | Permeability of the compound across artificial membrane by IAM binding assay | 2 | ALA5154913 | assay format | Scientific Literature | ||
11. | ALA5167235 | B | Binding affinity to AGP (unknown origin) assessed as maximum drug efficiency by HPLC analysis relative to control | Homo sapiens | 2 | ALA5154913 | assay format | Scientific Literature | |
12. | ALA5167236 | A | Binding affinity to human serum albumin by HPLC analysis relative to control | Homo sapiens | 2 | ALA5154913 | single protein format | Scientific Literature | |
13. | ALA5167237 | B | Binding affinity to alpha glycoprotein (unknown origin) by HPLC analysis relative to control | Homo sapiens | 2 | ALA5154913 | assay format | Scientific Literature |