| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5100431 | B | Positive allosteric modulator activity in human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as decrease in radioligand [125I]I-AB-MECA dissociation from A3AR receptor by measuring remaining radioligand-bound receptor at 10 uM preincubated for 2 hrs followed by AR agonist NECA addition and measured after 1 hr by radioligand competition binding assay relative to control (Rvb= 26%) | Homo sapiens | 27 | cell membrane format | Scientific Literature | ||
| 2. | ALA5100432 | B | Positive allosteric modulator activity in human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as net change in radioligand [125I]I-AB-MECA equilibrium binding to A3AR receptor at 10 uM incubated for 18 hrs by radioligand competition binding assay relative to control | Homo sapiens | 27 | cell membrane format | Scientific Literature | ||
| 3. | ALA5100433 | B | Positive allosteric modulator activity in wild type human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as increase in CI-IB-MECA induced [35S]GTPGAgammaS binding to receptor at 1 uM preincubated for 1 hrs with CI-IB-MECA further incubated with [35S]GTPGAgammaS for 2 hrs in presence of PSB-603,ZM241385 and ADP to degrade endogenous AR by liquid scintillation spectrometry | Homo sapiens | 32 | cell membrane format | Scientific Literature | ||
| 4. | ALA5100436 | B | Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 5. | ALA5100438 | B | Displacement of [3H]-DTG from human sigma2 receptor expressed in human HEK293T cell membrane incubated for 90 mins by radioligand binding assay | Homo sapiens | 9 | cell membrane format | Scientific Literature | ||
| 6. | ALA5100439 | B | Displacement of [3H]-N-methylspiperone from human D3 receptor expressed in human HEK293T cell membrane incubated for 90 mins by radioligand binding assay | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 7. | ALA5100443 | B | Inhibition of human TPSO receptor expressed in human HEK293T cell membrane incubated for 90 mins by radioligand binding assay | Homo sapiens | 2 | cell membrane format | Scientific Literature |
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