# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5158904 | F | Inhibition of gluconeogenesis in C57BL/6J mouse primary hepatocytes assessed as inhibition of glucagon-stimulated glucose production at 5 uM preincubated for 1.5 hrs followed by lactate and pyruvate addition and later stimulated with glucagon for 4 hrs | Mus musculus | 16 | ALA5154738 | cell-based format | Scientific Literature | |
2. | ALA5158905 | F | Inhibition of gluconeogenesis in C57BL/6J mouse primary hepatocytes assessed as inhibition of glucagon-stimulated glucose production at 2.5 uM preincubated for 1.5 hrs followed by lactate and pyruvate addition and later stimulated with glucagon for 4 hrs | Mus musculus | 16 | ALA5154738 | cell-based format | Scientific Literature | |
3. | ALA5158906 | T | Cytotoxicity against C57BL/6J mouse primary hepatocytes assessed as cell viability at 20 uM incubated for 24 hrs by MTT assay relative to control | Mus musculus | 16 | ALA5154738 | cell-based format | Scientific Literature | |
4. | ALA5158909 | F | Inhibition of gluconeogenesis in C57BL/6J mouse primary hepatocytes assessed as inhibition of glucagon-stimulated glucose production at 10 uM preincubated for 1.5 hrs followed by lactate and pyruvate addition and later stimulated with glucagon for 4 hrs | Mus musculus | 26 | ALA5154738 | cell-based format | Scientific Literature | |
5. | ALA5158910 | T | Cytotoxicity against C57BL/6J mouse primary hepatocytes assessed as cell viability at 10 uM incubated for 24 hrs by MTT assay relative to control | Mus musculus | 16 | ALA5154738 | cell-based format | Scientific Literature | |
6. | ALA5158911 | T | Cytotoxicity against C57BL/6J mouse primary hepatocytes assessed as cell viability at 50 uM incubated for 24 hrs by MTT assay relative to control | Mus musculus | 16 | ALA5154738 | cell-based format | Scientific Literature | |
7. | ALA5158912 | T | Cytotoxicity against C57BL/6J mouse primary hepatocytes assessed as cell viability at 100 uM incubated for 24 hrs by MTT assay relative to control | Mus musculus | 16 | ALA5154738 | cell-based format | Scientific Literature | |
8. | ALA5158913 | T | Cytotoxicity against C57BL/6J mouse primary hepatocytes assessed as cell viability at 200 uM incubated for 24 hrs by MTT assay relative to control | Mus musculus | 16 | ALA5154738 | cell-based format | Scientific Literature | |
9. | ALA5158914 | B | Activation of SIK1 in C57BL/6J mouse primary hepatocytes assessed as increase in SIK1 phosphorylation at Thr182 residue measured after 2 hrs by western blot analysis | Mus musculus | 3 | ALA5154738 | cell-based format | Scientific Literature |