| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5161145 | B | Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs in presence of ATP by electrophoretic analysis | Homo sapiens | 55 | ALA5154787 | single protein format | Scientific Literature | |
| 2. | ALA5161146 | B | Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis | Mus musculus | 47 | ALA5154787 | tissue-based format | Scientific Literature | |
| 3. | ALA5161147 | B | Inhibition of full length human AAK1 expressed in HEK293F cells assessed as suppression of AP2 phosphorylation measured after 3 hrs by Western blot analysis based cellular assay | Homo sapiens | 39 | ALA5154787 | cell-based format | Scientific Literature | |
| 4. | ALA5161148 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 51 | ALA5154787 | microsome format | Scientific Literature | |
| 5. | ALA5161149 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 51 | ALA5154787 | microsome format | Scientific Literature | |
| 6. | ALA5161150 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 51 | ALA5154787 | microsome format | Scientific Literature | |
| 7. | ALA5161151 | A | Inhibition of CYP3A4 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 48 | ALA5154787 | single protein format | Scientific Literature | |
| 8. | ALA5161243 | B | Inhibition of GAK (unknown origin) | Homo sapiens | 5 | ALA5154787 | single protein format | Scientific Literature | |
| 9. | ALA5161244 | B | Inhibition of MNK1 (unknown origin) | Homo sapiens | 7 | ALA5154787 | single protein format | Scientific Literature | |
| 10. | ALA5161246 | B | Inhibition of MYLK2 (unknown origin) | Homo sapiens | 5 | ALA5154787 | single protein format | Scientific Literature | |
| 11. | ALA5161247 | B | Inhibition of CRIK (unknown origin) | Homo sapiens | 5 | ALA5154787 | single protein format | Scientific Literature | |
| 12. | ALA5161260 | B | Inhibition of ROCK2 (unknown origin) | Homo sapiens | 5 | ALA5154787 | single protein format | Scientific Literature | |
| 13. | ALA5161262 | B | Inhibition of TNIK (unknown origin) | Homo sapiens | 2 | ALA5154787 | single protein format | Scientific Literature | |
| 14. | ALA5161274 | T | Cardiotoxicity in aortic ring (unknown origin) assessed as relaxation of phenylephrine induced aortic ring contraction at 10 uM incubated for 1 hr | Homo sapiens | 12 | ALA5154787 | tissue-based format | Scientific Literature |
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