| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5105455 | B | Agonist activity at human TLR2/TLR6 expressed in HEK-Blue hTLR2-TLR6 cells by SEAP reporter gene based Quanti-blue assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 2. | ALA5105456 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-6 production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 3. | ALA5105457 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-10 production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 4. | ALA5105458 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in TNF-alpha production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA5105463 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in CD40 expression incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 6. | ALA5105464 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in CD86 expression incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 7. | ALA5105465 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen dendritic cells assessed as increase in CD40 expression incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 8. | ALA5105466 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen dendritic cells assessed as increase in CD86 expression incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 9. | ALA5105467 | F | Immuno-adjuvant activity in C57BL/6 mouse immunized with recombinant hepatitis B surface antigen assessed as increase in anti-HBs antibody at 10 ug, IM administered twice 2 weeks apart by ELISA analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 10. | ALA5105468 | F | Immuno-adjuvant activity in C57BL/6 mouse immunized with recombinant hepatitis B surface antigen assessed as increase in IgG2/IgG1 ratio at 10 ug, IM administered twice 2 weeks apart by ELISA analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA5105469 | F | Immuno-adjuvant activity in C57BL/6 mouse immunized with recombinant influenza A/California/04/2009 HA protein assessed as increase in anti-HAs antibody at 10 ug, IM administered twice 2 weeks apart by ELISA analysis | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 12. | ALA5105470 | F | Protection against influenza A/California/04/2009 virus-challenged C57BL/6 mouse assessed as effect on body weight at 10 ug, IM administered twice 2 weeks apart along with recombinant influenza A/California/04/2009 HA protein immunization | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 13. | ALA5105471 | F | Protection against influenza A/California/04/2009 virus-challenged C57BL/6 mouse assessed as effect on survival at 10 ug, IM administered twice 2 weeks apart along with recombinant influenza A/California/04/2009 HA protein immunization | Mus musculus | 5 | organism-based format | Scientific Literature |
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