| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5125528 | B | Inhibition of mouse HDAC6 expressed in human HEK-293T cells using fluorescent peptide Ac-KGLGK(Ac)-MCA as substrate preincubated for 10 mins followed by substrate addition and measured after 1 hr by fluorogenic assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA5125529 | B | Inhibition of human HDAC1 expressed in human HEK-293T cells using fluorescent peptide RHKKAc as substrate preincubated for 10 mins followed by substrate addition and measured after 1 hr by fluorogenic assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA5125530 | B | Inhibition of human HDAC4 using fluorescent peptide Boc-Lys(trifluoroacetyl)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorogenic assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 4. | ALA5125531 | B | Selectivity ratio of IC50 for inhibition of human HDAC1 expressed in human HEK-293T cells using fluorescent peptide RHKKAc as substrate to IC50 for inhibition of mouse HDAC6 expressed in human HEK-293T cells using fluorescent peptide Ac-KGLGK(Ac)-MCA as substrate | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA5125532 | B | Selectivity ratio of IC50 for inhibition of human HDAC4 using fluorescent peptide Boc-Lys(trifluoroacetyl)-AMC as substrate to IC50 for inhibition of mouse HDAC6 expressed in human HEK-293T cells using fluorescent peptide Ac-KGLGK(Ac)-MCA as substrate | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA5125534 | T | Inhibition of human ERG potassium channel by fluorescence polarization assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 7. | ALA5125536 | P | Lipophilicity, logD of compound at pH 7.4 measured after 20 mins by UPLC analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5125537 | A | Apparent permeability in human Caco-2 cells incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA5125538 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 500 uM measured at 60 mins by LC-MS/MS analysis | Mus musculus | 3 | microsome format | Scientific Literature | ||
| 10. | ALA5125539 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 500 uM measured at 60 mins by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 11. | ALA5125540 | A | Brain to plasma ratio in C57BL/6J mouse at 10 mg/kg, iv measured after 45 mins by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA5125541 | F | Antidepressant activity in restraint-stressed C57BL/6J mouse model assessed as reduction in immobility time at 10 mg/kg, ip measured at 14 mins relative to control (Rvb= 569.6 +/- 27.6 sec) | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA5125543 | F | Antidepressant activity in restraint-stressed C57BL/6J mouse model assessed as increase in acetylated alpha tubulin level in brain at 10 mg/kg, ip measured after 15 mins | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5125544 | F | Antidepressant activity in restraint-stressed C57BL/6J mouse model assessed as change in acetylated histone H3K9 level in brain at 10 mg/kg, ip measured after 15 mins | Mus musculus | 1 | organism-based format | Scientific Literature |
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