#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA5123186	Functional	Inhibition of epithelial-mesenchymal transition in human HK-2 cells assessed as downregulation of uric acid-induced collagen-1 protein expression by Western blot analysis	Homo sapiens	1	ALA5120838	cell-based format	Scientific Literature
2.	ALA5123187	Functional	Anti-hyperuricemic activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in serum uric acid level at 5 mg/kg, po administered via gavage once daily for 4 weeks (Rvb = 356.15 +/- 3.31 uM)	Mus musculus	1	ALA5120838	organism-based format	Scientific Literature
3.	ALA5123188	Binding	Inhibition of bovine XOD assessed as inhibition of uric acid formation using xanthine as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured for 30 mins by microplate reader analysis	Bos taurus	42	ALA5120838	single protein format	Scientific Literature
4.	ALA5123189	Binding	Potency index, ratio of allopurinol IC50 to test compound IC50 for inhibition of bovine XOD assessed as inhibition of uric acid formation using xanthine as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured for 30 mins by microplate reader analysis	Bos taurus	4	ALA5120838	single protein format	Scientific Literature
5.	ALA5123190	Functional	Anti-hyperuricemic activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in serum uric acid level at 20 mg/kg, po administered via gavage once daily for 2 weeks (Rvb = 318.16 +/- 3.31 uM)	Mus musculus	5	ALA5120838	organism-based format	Scientific Literature
6.	ALA5123192	Functional	Anti-hyperuricemic activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in serum creatinine level at 20 mg/kg, po administered via gavage once daily for 2 weeks (Rvb = 87.62 +/- 0.67 uM)	Mus musculus	5	ALA5120838	organism-based format	Scientific Literature
7.	ALA5123194	Functional	Anti-hyperuricemic activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as blood urea nitrogen level at 20 mg/kg, po administered via gavage once daily for 2 weeks (Rvb = 9.88 +/- 1.21 mM)	Mus musculus	5	ALA5120838	organism-based format	Scientific Literature
8.	ALA5123196	Functional	Nephroprotective activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in renal tubule dilation at 20 mg/kg, po administered via gavage and measured after 21 days by hematoxylin-eosin and Masson trichrome staining based optical microscopic analysis	Mus musculus	5	ALA5120838	organism-based format	Scientific Literature
9.	ALA5123197	Functional	Nephroprotective activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in cytoplasmic vacuolation of renal tubular epithelial cells at 20 mg/kg, po administered via gavage and measured after 21 days by hematoxylin-eosin and Masson trichrome staining based optical microscopic analysis	Mus musculus	5	ALA5120838	organism-based format	Scientific Literature
10.	ALA5123198	Functional	Nephroprotective activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as appearance of clear tubular structures at 20 mg/kg, po administered via gavage and measured after 21 days by hematoxylin-eosin and Masson trichrome staining based optical microscopic analysis	Mus musculus	5	ALA5120838	organism-based format	Scientific Literature
11.	ALA5123199	Functional	Nephroprotective activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in connective tissue hyperplasia at 20 mg/kg, po administered via gavage and measured after 21 days by hematoxylin-eosin and Masson trichrome staining based optical microscopic analysis	Mus musculus	5	ALA5120838	organism-based format	Scientific Literature
12.	ALA5123200	Functional	Nephroprotective activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in neutrophils infiltrations at 20 mg/kg, po administered via gavage and measured after 21 days by hematoxylin-eosin and Masson trichrome staining based optical microscopic analysis	Mus musculus	5	ALA5120838	organism-based format	Scientific Literature
13.	ALA5123201	Functional	Nephroprotective activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in tubular-interstitial lesion development at 20 mg/kg, po administered via gavage and measured after 21 days by hematoxylin-eosin and Masson trichrome staining based optical microscopic analysis	Mus musculus	5	ALA5120838	organism-based format	Scientific Literature
14.	ALA5123202	Binding	Mixed type inhibition of bovine XOD assessed as decrease in Vmax with increase in Km at upto 20 uM using varying levels of xanthine as substrate by Lineweaver-Burk plot analysis	Bos taurus	1	ALA5120838	single protein format	Scientific Literature
15.	ALA5123203	Functional	Renal protective activity against po dosed adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in TGF-beta1 expression in kidney administered via gavage for 2 weeks by immunohistochemical staining based optical microscopic analysis	Mus musculus	1	ALA5120838	organism-based format	Scientific Literature
16.	ALA5123204	ADME	Stability in simulated gastric fluid assessed as parent compound remaining incubated for 4 hrs by HPLC analysis		1	ALA5120838	assay format	Scientific Literature
17.	ALA5123205	ADME	Stability in simulated intestinal fluid assessed as parent compound remaining incubated for 4 hrs by HPLC analysis		1	ALA5120838	assay format	Scientific Literature
18.	ALA5123206	Functional	Anti-hyperuricemic activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in serum uric acid level at 10 mg/kg, po administered via gavage once daily for 4 weeks (Rvb = 356.15 +/- 3.31 uM)	Mus musculus	1	ALA5120838	organism-based format	Scientific Literature
19.	ALA5123207	Functional	Anti-hyperuricemic activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in serum uric acid level at 20 mg/kg, po administered via gavage once daily for 4 weeks (Rvb = 356.15 +/- 3.31 uM)	Mus musculus	2	ALA5120838	organism-based format	Scientific Literature
20.	ALA5123208	Functional	Anti-hyperuricemic activity against adenine and potassium oxonate-induced hyperuricemia Kunming mouse model assessed as reduction in creatinine level at 5 mg/kg, po administered via gavage once daily for 4 weeks (Rvb = 76.87 +/- 0.67 uM)	Mus musculus	1	ALA5120838	organism-based format	Scientific Literature