# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5123484 | B | Inhibition of human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system incubated for 30 mins in presence of ATP by HTRF analysis | Homo sapiens | 30 | ALA5120851 | assay format | Scientific Literature | |
2. | ALA5123485 | B | Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system incubated for 30 mins in presence of ATP by HTRF analysis | Homo sapiens | 32 | ALA5120851 | assay format | Scientific Literature | |
3. | ALA5123486 | F | Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay | Homo sapiens | 30 | ALA5120851 | cell-based format | Scientific Literature | |
4. | ALA5123487 | F | Antiproliferative activity against human MOLM-14 cells assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay | Homo sapiens | 29 | ALA5120851 | cell-based format | Scientific Literature | |
5. | ALA5123488 | F | Antiproliferative activity against human MOLM-14 cells harboring FLT3 ITD/D835Y double mutant assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay | Homo sapiens | 29 | ALA5120851 | cell-based format | Scientific Literature | |
6. | ALA5123489 | B | Binding affinity to FLT3 ITD/F691L double mutant (unknown origin) by KINOMEscan assay | Homo sapiens | 1 | ALA5120851 | single protein format | Scientific Literature | |
7. | ALA5123490 | F | Antiproliferative activity against human MOLM-14 cells harboring FLT3 ITD/F691L double mutant assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay | Homo sapiens | 5 | ALA5120851 | cell-based format | Scientific Literature | |
8. | ALA5123491 | A | AUClast in ICR mouse at 10 mg/kg, iv measured upto 24 hrs | Mus musculus | 2 | ALA5120851 | organism-based format | Scientific Literature | |
9. | ALA5123492 | A | Clearance in ICR mouse at 10 mg/kg, iv measured upto 24 hrs | Mus musculus | 2 | ALA5120851 | organism-based format | Scientific Literature | |
10. | ALA5123493 | A | Volume of distribution at steady state in ICR mouse at 10 mg/kg, iv measured upto 24 hrs | Mus musculus | 2 | ALA5120851 | organism-based format | Scientific Literature | |
11. | ALA5123494 | A | Half life in ICR mouse at 10 mg/kg, iv measured upto 24 hrs | Mus musculus | 2 | ALA5120851 | organism-based format | Scientific Literature | |
12. | ALA5123495 | F | Antiproliferative activity against mouse BaF3 cells harboring FLT3 ITD mutant assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay | Mus musculus | 2 | ALA5120851 | cell-based format | Scientific Literature | |
13. | ALA5123496 | F | Antiproliferative activity against mouse BaF3 cells harboring FLT3 ITD/D835Y double mutant assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay | Mus musculus | 2 | ALA5120851 | cell-based format | Scientific Literature | |
14. | ALA5123497 | F | Antiproliferative activity against mouse BaF3 cells harboring FLT3 ITD/F691L double mutant assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay | Mus musculus | 2 | ALA5120851 | cell-based format | Scientific Literature | |
15. | ALA5123498 | B | Inhibition human recombinant His-tagged FLT3 kinase domain (564 to 958 residues) expressed in baculovirus expression system at 100 nM incubated for 30 mins in presence of ATP by HTRF analysis relative to control | Homo sapiens | 1 | ALA5120851 | assay format | Scientific Literature | |
16. | ALA5123499 | B | Inhibition of human recombinant His-tagged FLT3/D835Y mutant expressed in baculovirus expression system at 100 nM incubated for 30 mins in presence of ATP by HTRF analysis relative to control | Homo sapiens | 1 | ALA5120851 | assay format | Scientific Literature | |
17. | ALA5123500 | B | Inhibition of FLT3 ITD mutant (unknown origin) at 100 nM relative to control | Homo sapiens | 1 | ALA5120851 | single protein format | Scientific Literature | |
18. | ALA5123501 | B | Inhibition of FLT4 (unknown origin) at 100 nM relative to control | Homo sapiens | 1 | ALA5120851 | single protein format | Scientific Literature | |
19. | ALA5123502 | B | Inhibition of ARK5 (unknown origin) at 100 nM relative to control | Homo sapiens | 1 | ALA5120851 | single protein format | Scientific Literature | |
20. | ALA5123503 | B | Inhibition of NTRK2 (unknown origin) at 100 nM relative to control | Homo sapiens | 1 | ALA5120851 | single protein format | Scientific Literature |