# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5149834 | B | Inhibition of NLRP3 inflammasome in LPS-pretreated PBMC (unknown origin) assessed as reduction in IL-1beta release pretreated for 30 mins followed by ATP stimulated and measured after 1 hr by ELISA | Homo sapiens | 48 | cell-based format | Scientific Literature | ||
2. | ALA5149835 | A | Permeability of compound in pH 7.4 phosphate buffered saline at 10 uM measured after 4 hrs by PAMPA | 4 | assay format | Scientific Literature | |||
3. | ALA5149836 | P | Thermodynamic solubility of compound in pH 7.4 phosphate buffer incubated for 24 hrs under shaking condition by UPLC analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA5149837 | A | Protein binding in human plasma | Homo sapiens | 4 | cell-free format | Scientific Literature | ||
5. | ALA5149838 | A | Protein binding in rat plasma | Rattus norvegicus | 4 | cell-free format | Scientific Literature | ||
6. | ALA5149839 | A | Protein binding in mouse plasma | Mus musculus | 3 | cell-free format | Scientific Literature | ||
7. | ALA5149840 | B | Inhibition of NLRP3 inflammasome in LPS-pretreated human whole blood assessed as reduction in IL-1beta release pretreated for 30 mins followed by ATP stimulated and measured after 1 hr by HTRF assay | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
8. | ALA5149841 | B | Inhibition of NLRP3 inflammasome in LPS-pretreated human THP1-ASC-GFP cells assessed as reduction in speck positive cells measured after 30 mins in presence of caspase inhibitor zVAD-FMK by Hoechst 33342 staining based confocal microscopy | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
9. | ALA5149842 | T | Inhibition of LPS-stimulated IL-6 release in human PBMC measured after 4 hrs by ELISA | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
10. | ALA5149843 | T | Inhibition of LPS-stimulated TNF-alpha release in human PBMC measured after 4 hrs by ELISA | Homo sapiens | 4 | cell-based format | Scientific Literature |