| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5142321 | B | Inhibition of Influenza A virus A/PR/8/1934 (H1N1) neuraminidase using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method | Influenza A virus | 48 | ALA5137088 | single protein format | Scientific Literature | |
| 2. | ALA5142322 | B | Inhibition of Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) neuraminidase using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method | Influenza A virus | 48 | ALA5137088 | assay format | Scientific Literature | |
| 3. | ALA5142323 | B | Inhibition of Influenza A virus A/Goose/Jiangsu/1306/2014 (H5N8) neuraminidase using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method | Influenza A virus | 48 | ALA5137088 | assay format | Scientific Literature | |
| 4. | ALA5142324 | B | Inhibition of Influenza A virus A/Aichi/2/1968 (H3N2) neuraminidase using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method | Influenza A virus | 48 | ALA5137088 | assay format | Scientific Literature | |
| 5. | ALA5142325 | B | Inhibition of Influenza A virus A/California/04/2009 (H1N1) Neuraminidase H274Y mutant using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method | Influenza A virus | 15 | ALA5137088 | single protein format | Scientific Literature | |
| 6. | ALA5142326 | B | Inhibition of Influenza A virus A/Anhui/1/2005 (H5N1) Neuraminidase H274Y mutant using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method | Influenza A virus | 15 | ALA5137088 | assay format | Scientific Literature | |
| 7. | ALA5142327 | F | Antiviral activity against Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) infected in chick embryo fibroblast assessed as reduction in virus-induced cytopathic effect preincubated with virus for 30 mins followed by cell addition and measured after 48 hrs by CCK-8 assay | Influenza A virus | 11 | ALA5137088 | organism-based format | Scientific Literature | |
| 8. | ALA5142328 | F | Antiviral activity against Influenza A virus A/Goose/Jiangsu/1306/2014 (H5N8) infected in chick embryo fibroblast assessed as reduction in virus-induced cytopathic effect preincubated with virus for 30 mins followed by cell addition and measured after 48 hrs by CCK-8 assay | Influenza A virus | 11 | ALA5137088 | organism-based format | Scientific Literature | |
| 9. | ALA5142329 | T | Cytotoxicity against chick embryo fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay | Gallus gallus | 11 | ALA5137088 | cell-based format | Scientific Literature | |
| 10. | ALA5142330 | F | Antiviral activity against Influenza A virus A/PR/8/1934 (H1N1) infected in MDCK cells assessed as inhibition of plaque formation incubated for 2 hrs by plaque reduction assay | Influenza A virus | 11 | ALA5137088 | organism-based format | Scientific Literature | |
| 11. | ALA5142331 | T | Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Canis lupus familiaris | 11 | ALA5137088 | cell-based format | Scientific Literature | |
| 12. | ALA5142332 | F | Antiviral activity against Influenza A virus A/WSN/67/05 (H3N2) infected in MDCK cells assessed as inhibition of plaque formation incubated for 2 hrs by plaque reduction assay | Influenza A virus | 11 | ALA5137088 | organism-based format | Scientific Literature | |
| 13. | ALA5142347 | A | Metabolic stability in human liver microsomes assessed as half-life preincubated for 10 mins followed by NADPH addition for 2 hrs and measured upto 60 mins by high performance liquid chromatography-tandem mass spectrometry | Homo sapiens | 10 | ALA5137088 | microsome format | Scientific Literature | |
| 14. | ALA5142348 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance preincubated for 10 mins followed by NADPH addition for 2 hrs and measured upto 60 mins by high performance liquid chromatography-tandem mass spectrometry | Homo sapiens | 10 | ALA5137088 | microsome format | Scientific Literature | |
| 15. | ALA5142349 | A | Metabolic stability in human liver assessed as intrinsic clearance preincubated for 10 mins followed by NADPH addition for 2 hrs and measured upto 60 mins by high performance liquid chromatography-tandem mass spectrometry | Homo sapiens | 10 | ALA5137088 | tissue-based format | Scientific Literature | |
| 16. | ALA5142350 | A | Metabolic stability in human liver assessed as parent compound remaining preincubated for 10 mins followed by NADPH addition for 2 hrs and measured at 60 mins by high performance liquid chromatography-tandem mass spectrometry | Homo sapiens | 10 | ALA5137088 | tissue-based format | Scientific Literature | |
| 17. | ALA5142352 | T | Toxicity in chicken embryo infected with Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) assessed as survival rate at 10 mM preincubated for 1 hrs followed by infection with embryo and measured at 24 hrs relative to control | Gallus gallus | 4 | ALA5137088 | tissue-based format | Scientific Literature | |
| 18. | ALA5142353 | T | Toxicity in chicken embryo infected with Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) assessed as survival rate at 2.5 mM preincubated for 1 hrs followed by infection with embryo and measured at 24 hrs relative to control | Gallus gallus | 4 | ALA5137088 | tissue-based format | Scientific Literature | |
| 19. | ALA5142354 | T | Toxicity in chicken embryo infected with Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) assessed as survival rate at 0.625 mM preincubated for 1 hrs followed by infection with embryo and measured at 24 hrs relative to control | Gallus gallus | 4 | ALA5137088 | tissue-based format | Scientific Literature | |
| 20. | ALA5142355 | T | Toxicity in chicken embryo infected with Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) assessed as survival rate at 0.156 mM preincubated for 1 hrs followed by infection with embryo and measured at 24 hrs relative to control | Gallus gallus | 4 | ALA5137088 | tissue-based format | Scientific Literature |
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