# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5115803 | B | Protac activity at CRBN/EGFR wild type in human A549 cells assessed as EGFR degradation at 3 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
2. | ALA5115804 | B | Protac activity at CRBN/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as L858R/T790M mutant degradation at 3 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
3. | ALA5115805 | B | Protac activity at CRBN/EGFR Del19 mutant in human PC-9 cells assessed as L858R/T790M mutant degradation at 3 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
4. | ALA5115836 | F | Anti-proliferative activity against human A549 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
5. | ALA5115837 | F | Anti-proliferative activity against human PC-9 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
6. | ALA5115838 | F | Anti-proliferative activity against human NCI-H1975 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
7. | ALA5115839 | B | Inhibition of wild type EGFR (unknown origin) incubated for 10 mins by HTRF KinEASE-TK assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
8. | ALA5115840 | B | Inhibition of EGFR L858R/T790M mutant (unknown origin) incubated for 35 mins by HTRF KinEASE-TK assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
9. | ALA5115841 | B | Selectivity index, ratio of IC50 for wild type EGFR (unknown origin) to IC50 for Protein cereblon/Epidermal growth factor receptor L858R/T790M mutant | Homo sapiens | 8 | assay format | Scientific Literature |