| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5167811 | B | Relative binding affinity to human ERalpha measured after 2 hrs by competitive fluorometric binding assay relative to estradiol | Homo sapiens | 24 | ALA5154927 | single protein format | Scientific Literature | |
| 2. | ALA5167812 | B | Relative binding affinity to human ERbeta measured after 2 hrs by competitive fluorometric binding assay relative to estradiol | Homo sapiens | 24 | ALA5154927 | single protein format | Scientific Literature | |
| 3. | ALA5167813 | B | Selectivity ratio of relative binding affinity for human ERalpha to relative binding affinity for human ERbeta | Homo sapiens | 24 | ALA5154927 | assay format | Scientific Literature | |
| 4. | ALA5167814 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by Cell Counting Kit-8 assay | Homo sapiens | 24 | ALA5154927 | cell-based format | Scientific Literature | |
| 5. | ALA5167815 | F | Antiproliferative activity against tamoxifen-resistant human LCC2 cells assessed as reduction in cell viability measured after 72 hrs by Cell Counting Kit-8 assay | Homo sapiens | 24 | ALA5154927 | cell-based format | Scientific Literature | |
| 6. | ALA5167816 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by Cell Counting Kit-8 assay | Homo sapiens | 24 | ALA5154927 | cell-based format | Scientific Literature | |
| 7. | ALA5167817 | T | Antiproliferative activity against human MCF-10A cells assessed as reduction in cell viability measured after 72 hrs by Cell Counting Kit-8 assay | Homo sapiens | 24 | ALA5154927 | cell-based format | Scientific Literature | |
| 8. | ALA5167818 | T | Selectivity index, ratio of IC50 for human MCF-10A cells to IC50 for human MCF-7 cells | Homo sapiens | 24 | ALA5154927 | assay format | Scientific Literature | |
| 9. | ALA5167819 | F | Potency index, ratio of 4-OHT IC50 to test compound IC50 for antiproliferative activity against human MCF7 cells | Homo sapiens | 1 | ALA5154927 | cell-based format | Scientific Literature | |
| 10. | ALA5167820 | F | Potency index, ratio of 4-OHT IC50 to test compound IC50 for antiproliferative activity against human LCC2 cells | Homo sapiens | 1 | ALA5154927 | cell-based format | Scientific Literature | |
| 11. | ALA5167821 | F | Potency index, ratio of 4-OHT IC50 to test compound IC50 for antiproliferative activity against human MDA-MB-231 cells | Homo sapiens | 1 | ALA5154927 | cell-based format | Scientific Literature | |
| 12. | ALA5167822 | B | Antagonist activity at ERalpha expressed in human HEK293T cells measured after 24 hrs by dual luciferase reporter assay | Homo sapiens | 1 | ALA5154927 | cell-based format | Scientific Literature | |
| 13. | ALA5167823 | B | Antagonist activity at ERalpha expressed in human HEK293T cells measured after 24 hrs by dual luciferase reporter assay relative to estradiol | Homo sapiens | 1 | ALA5154927 | cell-based format | Scientific Literature | |
| 14. | ALA5167824 | B | Binding affinity to hexokinase-1 in human MCF7 cell lysate measured after overnight incubation by LC-MS/MS analysis | Homo sapiens | 1 | ALA5154927 | subcellular format | Scientific Literature | |
| 15. | ALA5167825 | B | Inhibition of human recombinant hexokinase-1 assessed as NADPH generation measured after 1 hr by HPLC analysis | Homo sapiens | 1 | ALA5154927 | single protein format | Scientific Literature | |
| 16. | ALA5167826 | F | Downregulation of hexokinase-1 expression in human MCF7 cell mitochondria at 16 uM measured after 24 hrs by DAPI staining based immunofluorescence microscopy | Homo sapiens | 1 | ALA5154927 | mitochondrion format | Scientific Literature | |
| 17. | ALA5167827 | F | Downregulation of hexokinase-1 expression in tamoxifen-resistant human LCC2 cell mitochondria at 20 uM measured after 24 hrs by DAPI staining based immunofluorescence microscopy | Homo sapiens | 1 | ALA5154927 | mitochondrion format | Scientific Literature | |
| 18. | ALA5167828 | F | Downregulation of hexokinase-1 expression in human MCF7 cell outer mitochondrial membrane at 1 to 16 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5154927 | mitochondrion format | Scientific Literature | |
| 19. | ALA5167829 | F | Downregulation of hexokinase-1 expression in tamoxifen-resistant human LCC2 cell outer mitochondrial membrane measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5154927 | mitochondrion format | Scientific Literature | |
| 20. | ALA5167830 | F | Inhibition of glycolysis in human MCF7 cells assessed as decrease in glucose-6-phosphate level at 15 uM measured after 12 hrs by LC-MS/MS analysis | Homo sapiens | 1 | ALA5154927 | cell-based format | Scientific Literature |
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