# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5112518 | B | Destabilization of N-terminal His-6 tagged OTUB1 (40 to 271 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in melting temperature at 200 uM measured for 2 hrs in presence of dithiothreitol by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA5108067 | cell-based format | Scientific Literature | |
2. | ALA5112519 | B | Inhibition of N-terminal His-6 tagged OTUB1 (40 to 271 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells at 10 nM using Ub-Rho measured after 0.5 to 3 hrs by fluorescence based Plate reader method relative to control | Homo sapiens | 68 | ALA5108067 | cell-based format | Scientific Literature | |
3. | ALA5112520 | B | Inhibition of N-terminal His-6 tagged OTUB1 (40 to 271 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells at 100 nM using Ub-Rho measured after 0.5 to 3 hrs by fluorescence based Plate reader method relative to control | Homo sapiens | 68 | ALA5108067 | cell-based format | Scientific Literature | |
4. | ALA5112521 | B | Inhibition of N-terminal His-6 tagged USP8 (734 to 1110 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells at 10 nM measured after 3 hrs by fluorescence based Plate reader method relative to control | Homo sapiens | 68 | ALA5108067 | cell-based format | Scientific Literature | |
5. | ALA5112522 | B | Inhibition of N-terminal His-6 tagged USP8 (734 to 1110 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells at 100 nM measured after 3 hrs by fluorescence based Plate reader method relative to control | Homo sapiens | 68 | ALA5108067 | cell-based format | Scientific Literature | |
6. | ALA5112524 | P | Aqueous solubility of the compound measured after 24 hr by UV irradiation based LC-MS/MS analysis | 10 | ALA5108067 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5112525 | B | Inhibition of N-terminal His-6 tagged OTUB1 (40 to 271 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Ub-Rho measured after 0.5 to 3 hrs by fluorescence based Plate reader method | Homo sapiens | 6 | ALA5108067 | cell-based format | Scientific Literature | |
8. | ALA5112526 | B | Inhibition of N-terminal His-6 tagged USP8 (734 to 1110 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells measured after 3 hrs by fluorescence based Plate reader method | Homo sapiens | 4 | ALA5108067 | cell-based format | Scientific Literature | |
9. | ALA5112527 | B | Inhibition of USP1 (unknown origin) using Ub-Rho measured after 0.5 to 3 hrs | Homo sapiens | 4 | ALA5108067 | single protein format | Scientific Literature | |
10. | ALA5112528 | B | Inhibition of USP2 (unknown origin) using Ub-Rho measured after 0.5 to 3 hrs | Homo sapiens | 4 | ALA5108067 | single protein format | Scientific Literature | |
11. | ALA5112529 | B | Inhibition of USP7 (unknown origin) using Ub-Rho measured after 0.5 to 3 hrs | Homo sapiens | 4 | ALA5108067 | single protein format | Scientific Literature | |
12. | ALA5112530 | B | Inhibition of USP36 (unknown origin) using Ub-Rho measured after 0.5 to 3 hrs | Homo sapiens | 4 | ALA5108067 | single protein format | Scientific Literature | |
13. | ALA5112531 | B | Inhibition of Ataxin-3 (unknown origin) using Ub-Rho measured after 0.5 to 3 hrs | Homo sapiens | 4 | ALA5108067 | single protein format | Scientific Literature | |
14. | ALA5112533 | F | Antiproliferative activity against human NCI-H1975 cells harboring wild type KRAS incubated for 72 hrs by MTT assay | Homo sapiens | 4 | ALA5108067 | cell-based format | Scientific Literature | |
15. | ALA5112534 | F | Antiproliferative activity against human EBC-1 cells harboring wild type KRAS incubated for 72 hrs by MTT assay | Homo sapiens | 4 | ALA5108067 | cell-based format | Scientific Literature | |
16. | ALA5112535 | F | Antiproliferative activity against human NCI-H1703 cells harboring wild type KRAS incubated for 72 hrs by MTT assay | Homo sapiens | 4 | ALA5108067 | cell-based format | Scientific Literature | |
17. | ALA5112536 | F | Antiproliferative activity against human NCI-H23 cells harboring KRAS mutant incubated for 72 hrs by MTT assay | Homo sapiens | 4 | ALA5108067 | cell-based format | Scientific Literature | |
18. | ALA5112537 | F | Antiproliferative activity against human A549 cells harboring KRAS mutant incubated for 72 hrs by MTT assay | Homo sapiens | 4 | ALA5108067 | cell-based format | Scientific Literature | |
19. | ALA5112540 | A | Half life in ICR mouse at 1 mg/kg, iv measured upto 1440 mins by LC-MS/MS analysis | Mus musculus | 2 | ALA5108067 | organism-based format | Scientific Literature | |
20. | ALA5112541 | A | Half life in ICR mouse at 10 mg/kg, po measured upto 1440 mins by LC-MS/MS analysis | Mus musculus | 2 | ALA5108067 | organism-based format | Scientific Literature |