Activation of human recombinant AMPK A2/B2/G1 assessed as increase in AMPK phosphorylation using FL-peptide as substrate incubated for 120 mins by EZ reader method
Antidiabetic activity against type 2 diabetic KKAy mouse model assessed as increase in Akt phosphorylation in skeletal muscle at 1.5 to 6 mg/kg,po bid measured on 25 to 26 days after insulin injection by ELISA
Antidiabetic activity against type 2 diabetic KKAy mouse model assessed as decrease in lipid accumulation in liver at 1.5 to 6 mg/kg,po bid measured on 25 to 26 days after insulin injection
Antidiabetic activity against type 2 diabetic KKAy mouse model assessed as decrease in plasma glucose level administrated orally bid measured after 21 days of administration by automatic analyzer
Antidiabetic activity against type 2 diabetic KKAy mouse model assessed as decrease in HbA1c level administrated orally bid measured after 21 days of administration by automatic analyzer