# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5106581 | Functional | Cytotoxicity against human T98G cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by MTS assay | Homo sapiens | 5 | ALA5104176 | cell-based format | Scientific Literature | |
2. | ALA5106582 | Binding | Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293T cell membrane incubated for 1 hr by MicroBeta scintillation counting method | Homo sapiens | 30 | ALA5104176 | cell membrane format | Scientific Literature | |
3. | ALA5106583 | Binding | Displacement of [3H]N-methylspiperone from human D3R receptor expressed in HEK293T cell membrane incubated for 1 hr by MicroBeta scintillation counting method | Homo sapiens | 30 | ALA5104176 | cell membrane format | Scientific Literature | |
4. | ALA5106584 | Binding | Displacement of [3H]N-methylspiperone from human D4.4 receptor expressed in HEK293T cell membrane incubated for 1 hr by MicroBeta scintillation counting method | Homo sapiens | 30 | ALA5104176 | cell membrane format | Scientific Literature | |
5. | ALA5106585 | Binding | Selectivity ratio of pKi for displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293T cell membrane to pKi for displacement of [3H]N-methylspiperone from human D4.4 receptor expressed in HEK293T cell membrane | 30 | ALA5104176 | cell-based format | Scientific Literature | ||
6. | ALA5106586 | Binding | Selectivity ratio of pKi for displacement of [3H]N-methylspiperone from human D3R expressed in HEK293T cell membrane to pKi for displacement of [3H]N-methylspiperone from human D4.4 receptor expressed in HEK293T cell membrane | 30 | ALA5104176 | cell-based format | Scientific Literature | ||
7. | ALA5106587 | Functional | Antagonist activity at D4R (unknown origin) expressed in human HEK293T cells assessed as inhibition of dopamine-induced G0 protein activation pretreated for 10 mins followed by dopamine addition and measured after 2.5 mins by BRET assay | Homo sapiens | 5 | ALA5104176 | cell-based format | Scientific Literature | |
8. | ALA5106588 | Functional | Antagonist activity at D4R (unknown origin) expressed in human HEK293T cells assessed as inhibition of dopamine-induced Gi protein activation pretreated for 10 mins followed by dopamine addition and measured after 2.5 mins by BRET assay | Homo sapiens | 5 | ALA5104176 | cell-based format | Scientific Literature | |
9. | ALA5106589 | Functional | Antagonist activity at D4R (unknown origin) expressed in human HEK293T cells assessed as inhibition of dopamine-induced beta arrestin-2 recruitment pretreated for 10 mins followed by dopamine addition and measured after 2.5 mins by BRET assay | Homo sapiens | 5 | ALA5104176 | cell-based format | Scientific Literature | |
10. | ALA5106590 | Functional | Antagonist activity at D4R (unknown origin) expressed in human HEK293T cells assessed as inhibition of dopamine-induced G0 protein activation pretreated for 10 mins followed by dopamine addition and measured after 2.5 mins by BRET assay relative to control | Homo sapiens | 5 | ALA5104176 | cell-based format | Scientific Literature | |
11. | ALA5106591 | Functional | Antagonist activity at D4R (unknown origin) expressed in human HEK293T cells assessed as inhibition of dopamine-induced Gi protein activation pretreated for 10 mins followed by dopamine addition and measured after 2.5 mins by BRET assay relative to control | Homo sapiens | 5 | ALA5104176 | cell-based format | Scientific Literature | |
12. | ALA5106592 | Functional | Antagonist activity at D4R (unknown origin) expressed in human HEK293T cells assessed as inhibition of dopamine-induced beta arrestin-2 recruitment pretreated for 10 mins followed by dopamine addition and measured after 2.5 mins by BRET assay relative to control | Homo sapiens | 5 | ALA5104176 | cell-based format | Scientific Literature | |
13. | ALA5106593 | Functional | Cytotoxicity against human U-251 cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by MTS assay | Homo sapiens | 5 | ALA5104176 | cell-based format | Scientific Literature | |
14. | ALA5106594 | Functional | Cytotoxicity against human GSC#83 cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by MTS assay | Homo sapiens | 5 | ALA5104176 | cell-based format | Scientific Literature | |
15. | ALA5106595 | Functional | Cytotoxicity against human T98G cells assessed as reduction in cell viability at 10 uM incubated for 24 hrs by MTS assay | Homo sapiens | 4 | ALA5104176 | cell-based format | Scientific Literature | |
16. | ALA5106596 | Functional | Cytotoxicity against human U-251 cells assessed as reduction in cell viability at 10 uM incubated for 24 hrs by MTS assay | Homo sapiens | 4 | ALA5104176 | cell-based format | Scientific Literature | |
17. | ALA5106597 | Functional | Cytotoxicity against human GSC#83 cells assessed as reduction in cell viability at 10 uM incubated for 24 hrs by MTS assay | Homo sapiens | 4 | ALA5104176 | cell-based format | Scientific Literature | |
18. | ALA5106598 | Functional | Cytotoxicity against human T98G cells assessed as reduction in cell viability at 10 uM incubated for 24 hrs in presence of 10 uM D4 receptor agonist, A412997 by MTS assay | Homo sapiens | 2 | ALA5104176 | cell-based format | Scientific Literature | |
19. | ALA5106599 | Binding | Displacement of [3H]7-OH-DPAT from human D4.4 receptor expressed in HEK293T cell membrane incubated for 1.5 hrs by MicroBeta scintillation counting method | Homo sapiens | 3 | ALA5104176 | cell membrane format | Scientific Literature | |
20. | ALA5106600 | Functional | Agonist activity at D4R (unknown origin) expressed in human HEK293T cells assessed as G0 protein activation measured after 2.5 mins by BRET assay | Homo sapiens | 4 | ALA5104176 | cell-based format | Scientific Literature |