# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5111721 | Functional | Anti-necroptic activity in mouse MEF cells assessed as inhibition of TSZ (TNFalpha, Smac mimetic and z-VAD-FMK) induced necroptosis incubated for 24 hrs by celltiter-glo luminescent cell viability assay | Mus musculus | 5 | ALA5108050 | cell-based format | Scientific Literature | |
2. | ALA5111726 | Binding | Inhibition of human MLKL in human HT-29 cells assessed as inhibition of TSZ (TNFalpha, Smac mimetic and z-VAD-FMK) induced MLKL oligomerization at 5 uM and measured after 6 hrs by immunoblot assay | Homo sapiens | 1 | ALA5108050 | cell-based format | Scientific Literature | |
3. | ALA5111730 | Functional | Anti-necroptic activity in human HT-29 KO cells expressing MLKL C18S mutant assessed as inhibition of TSZ (TNFalpha, Smac mimetic and z-VAD-FMK) induced MLKL C18S mutant mediated necroptosis incubated for 24 hrs by celltiter-glo luminescent cell viability assay | Homo sapiens | 4 | ALA5108050 | cell-based format | Scientific Literature | |
4. | ALA5111731 | Functional | Anti-necroptic activity in human HT-29 KO cells expressing MLKL F148A mutant assessed as inhibition of TSZ (TNFalpha, Smac mimetic and z-VAD-FMK) induced MLKL F148A mutant mediated necroptosis incubated for 24 hrs by celltiter-glo luminescent cell viability assay | Homo sapiens | 4 | ALA5108050 | cell-based format | Scientific Literature | |
5. | ALA5111732 | Functional | Anti-necroptic activity in human HT-29 KO cells expressing MLKL K157A mutant assessed as inhibition of TSZ (TNFalpha, Smac mimetic and z-VAD-FMK) induced MLKL K157A mutant mediated necroptosis incubated for 24 hrs by celltiter-glo luminescent cell viability assay | Homo sapiens | 4 | ALA5108050 | cell-based format | Scientific Literature |