PROTAC activity at CRBN/BRD4 (unknown origin) assessed as BRD4 degradation in presence of N-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl)-3,4- dihydroxy benzamide (CRB-N8046) by Western blot analysis
PROTAC activity at CRBN/BRD4 (unknown origin) assessed as BRD4 degradation in presence of N-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl)-2,3- dihydroxy benzamide (CRB-N8047) by Western blot analysis
PROTAC activity at CRBN/BRD4 (unknown origin) assessed as BRD4 degradation in presence of (1S,4R,5R,6S)-N-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl)-5,6- dihydroxy bicyclo[2.2.1]heptane-2-carboxamide (CRB-N8066) by Western blot analysis