| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5130547 | B | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by measuring efficacy at 100 nM measured at 180 sec by fluorescence based microplate reader analysis relative to capsaicin | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 2. | ALA5130548 | B | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation measured at 180 sec by fluorescence based microplate reader analysis | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
| 3. | ALA5130551 | B | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as activation of TRPV1 current at 1 uM at 0 mV holding potential by whole-cell patch clamp assay relative to capsaicin | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA5130552 | B | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as desensitization of TRPV1 current at 1 uM at 0 mV holding potential with repetitive drug application by whole-cell patch clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA5130554 | B | Agonist activity at mouse TRPV1 expressed in HEK293 cells assessed as activation of TRPV1 current by measuring efficacy at 1 uM at 0 mV holding potential by whole-cell patch clamp assay relative to capsaicin | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5130555 | B | Agonist activity at rat TRPV1 expressed in HEK293 cells assessed as activation of TRPV1 current by measuring efficacy at 1 uM at 0 mV holding potential by whole-cell patch clamp assay relative to capsaicin | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5130556 | B | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as induction of calcium influx by measuring increase in intracellular fluorescence intensity at 1 uM measured for 180 sec by Fluo-8 based calcium imaging analysis relative to ionomycin | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA5130557 | B | Agonist activity at mouse TRPV2 assessed as activation of TRPV2 current at 1 uM at 0 mV holding potential by whole-cell patch clamp assay relative to 2-APB | Mus musculus | 1 | assay format | Scientific Literature | ||
| 9. | ALA5130558 | B | Agonist activity at human TRPV3 assessed as activation of TRPV3 current at 1 uM at 0 mV holding potential by whole-cell patch clamp assay relative to 2-APB | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA5130559 | B | Agonist activity at mouse TRPV4 assessed as activation of TRPV4 current at 1 uM at 0 mV holding potential by whole-cell patch clamp assay relative to GSK1016790A | Mus musculus | 1 | assay format | Scientific Literature | ||
| 11. | ALA5130560 | B | Agonist activity at human TRPA1 assessed as activation of TRPV4 current at 1 uM at 0 mV holding potential by whole-cell patch clamp assay relative to AITC | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA5130561 | A | Metabolic stability in human liver microsomes assessed as half-life at 10 mM measured upto 45 mins in the presence of NADPH by LC/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 13. | ALA5130562 | A | Metabolic stability in mouse liver microsomes assessed as half-life at 10 mM measured upto 45 mins in the presence of NADPH by LC/MS analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 14. | ALA5130563 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 10 mM measured upto 45 mins in the presence of NADPH by LC/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 15. | ALA5130564 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 10 mM measured upto 45 mins in the presence of NADPH by LC/MS analysis | Mus musculus | 2 | microsome format | Scientific Literature | ||
| 16. | ALA5130565 | A | Metabolic stability in human liver microsomes assessed as clearance at 10 mM measured upto 45 mins in the presence of NADPH by LC/MS analysis relative to hepatic blood flow | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 17. | ALA5130566 | A | Metabolic stability in mouse liver microsomes assessed as clearance at 10 mM measured upto 45 mins in the presence of NADPH by LC/MS analysis relative to hepatic blood flow | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 18. | ALA5130567 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 10 mM measured at 30 mins in the presence of NADPH by LC/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 19. | ALA5130568 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 10 mM measured at 30 mins in the presence of NADPH by LC/MS analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 20. | ALA5130569 | F | Induction of hypothermia in C57BL/6 mouse assessed as decrease in body temperature at 1 mg/kg, ip measured at 1 hrs by rectal measurement method | Mus musculus | 1 | organism-based format | Scientific Literature |
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