| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5132116 | F | Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay | Human immunodeficiency virus 1 | 24 | ALA5131381 | organism-based format | Scientific Literature | |
| 2. | ALA5132117 | F | Antiviral activity against HIV-1 ROD infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay | Human immunodeficiency virus 1 | 24 | ALA5131381 | organism-based format | Scientific Literature | |
| 3. | ALA5132118 | F | Selectivity ratio, ratio of EC50 for antiviral activity against HIV-1 3B infected in human MT4 cells to EC50 for antiviral activity against HIV-1 ROD infected in human MT4 cells | 24 | ALA5131381 | cell-based format | Scientific Literature | ||
| 4. | ALA5132119 | T | Cytotoxicity against mock infected human MT4 cells by MTT assay | Homo sapiens | 24 | ALA5131381 | cell-based format | Scientific Literature | |
| 5. | ALA5132120 | T | Selectivity index, ratio of CC50 for cytotoxicity against mock infected human MT4 cells to EC50 for antiviral activity against HIV-1 3B infected in human MT4 cells | 24 | ALA5131381 | cell-based format | Scientific Literature | ||
| 6. | ALA5132121 | T | Selectivity index, ratio of CC50 for cytotoxicity against mock infected human MT4 cells to EC50 for antiviral activity against HIV-1 ROD infected in human MT4 cells | 24 | ALA5131381 | cell-based format | Scientific Literature | ||
| 7. | ALA5132122 | B | Binding affinity to HIV-1 NL4-3 capsid protein monomer assessed as dissociation constant by SPR analysis | Human immunodeficiency virus 1 | 3 | ALA5131381 | single protein format | Scientific Literature | |
| 8. | ALA5132123 | B | Binding affinity to HIV-1 NL4-3 capsid protein hexamer assessed as dissociation constant by SPR analysis | Human immunodeficiency virus 1 | 3 | ALA5131381 | single protein format | Scientific Literature | |
| 9. | ALA5132124 | B | Binding affinity to HIV-1 NL4-3 capsid protein monomer assessed as Koff by SPR analysis | Human immunodeficiency virus 1 | 3 | ALA5131381 | single protein format | Scientific Literature | |
| 10. | ALA5132125 | B | Binding affinity to HIV-1 NL4-3 capsid protein hexamer assessed as Koff by SPR analysis | Human immunodeficiency virus 1 | 3 | ALA5131381 | single protein format | Scientific Literature | |
| 11. | ALA5132126 | B | Selectivity ratio, ratio of Kd for binding affinity to HIV1 NL4-3 capsid protein monomer to Kd for binding affinity to HIV1 NL4-3 capsid protein hexamer | 3 | ALA5131381 | assay format | Scientific Literature | ||
| 12. | ALA5132127 | A | Metabolic stability in human liver microsomes assessed as half life | Homo sapiens | 6 | ALA5131381 | microsome format | Scientific Literature | |
| 13. | ALA5132128 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 6 | ALA5131381 | microsome format | Scientific Literature | |
| 14. | ALA5132129 | A | Metabolic stability in human liver assessed as intrinsic clearance | Homo sapiens | 6 | ALA5131381 | tissue-based format | Scientific Literature | |
| 15. | ALA5132130 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining measured after 60 mins | Homo sapiens | 6 | ALA5131381 | microsome format | Scientific Literature | |
| 16. | ALA5132131 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining measured after 60 mins in absence of NADPH | Homo sapiens | 6 | ALA5131381 | microsome format | Scientific Literature | |
| 17. | ALA5132132 | A | Metabolic stability in human plasma assessed as parent compound remaining measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5131381 | cell-free format | Scientific Literature | |
| 18. | ALA5132133 | F | Antiviral activity against HIV-1 NL4-3 Env-deficient pseudotype virus infected in U87/CD4/CCR5 cells assessed as reduction in viral infection in early stage measured after 48 hrs by luciferase activity based single-round infection assay | Human immunodeficiency virus 1 | 1 | ALA5131381 | organism-based format | Scientific Literature | |
| 19. | ALA5132134 | F | Antiviral activity against HIV-1 NL4-3 Env-deficient pseudotype virus infected in U87/CD4/CCR5 cells assessed as reduction in viral infection in late stage measured after 48 hrs by luciferase activity based single-round infection assay | Human immunodeficiency virus 1 | 1 | ALA5131381 | organism-based format | Scientific Literature |
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