# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5166476 | B | Displacement of [3H]HOCPCA from CaMK2alpha in rat brain cerebral cortex membrane homogenates assessed as inhibition constant measured after 60 mins by TopCount scintillation counting method | Rattus norvegicus | 4 | ALA5154898 | cell membrane format | Scientific Literature | |
2. | ALA5166478 | B | Displacement of [3H]NCS-382 from CaMK2alpha in rat brain cerebral cortex membrane homogenates assessed as inhibition constant measured after 60 mins by TopCount scintillation counting method | Rattus norvegicus | 21 | ALA5154898 | cell membrane format | Scientific Literature | |
3. | ALA5166480 | A | Plasma concentration in C57BL/6J mouse at 10 mg/kg , po measured after 30 mins by UPLC based tandem mass spectrometry analysis | Mus musculus | 2 | ALA5154898 | organism-based format | Scientific Literature | |
4. | ALA5166481 | B | Binding affinity to recombinant human CaMK2alpha Thr354Asn mutant expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by surface plasmon resonance assay | Homo sapiens | 4 | ALA5154898 | assay format | Scientific Literature | |
5. | ALA5166483 | B | Binding affinity to recombinant human CaMK2alpha Glu355Gln mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay | Homo sapiens | 4 | ALA5154898 | assay format | Scientific Literature | |
6. | ALA5166484 | B | Binding affinity to recombinant human CaMK2alpha Thr412Asn mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay | Homo sapiens | 4 | ALA5154898 | assay format | Scientific Literature | |
7. | ALA5166485 | B | Binding affinity to recombinant human CaMK2alpha Ile414Met mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay | Homo sapiens | 4 | ALA5154898 | assay format | Scientific Literature | |
8. | ALA5166486 | B | Binding affinity to recombinant human CaMK2alpha Ile464His mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay | Homo sapiens | 4 | ALA5154898 | assay format | Scientific Literature | |
9. | ALA5166487 | B | Binding affinity to recombinant human CaMK2alpha Phe467Met mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay | Homo sapiens | 4 | ALA5154898 | assay format | Scientific Literature | |
10. | ALA5166497 | A | Brain concentration in C57BL/6J mouse at 10 mg/kg , po measured after 30 mins by UPLC based tandem mass spectrometry analysis | Mus musculus | 2 | ALA5154898 | organism-based format | Scientific Literature | |
11. | ALA5166499 | A | Ratio of drug concentration in brain to plasma in C57BL/6J mouse at 10 mg/kg , po measured after 30 mins by UPLC based tandem mass spectrometry analysis | Mus musculus | 2 | ALA5154898 | organism-based format | Scientific Literature |