| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5164475 | F | Anti-colitis activity against DSS-induced C57BL/6 mouse model of acute colitis assessed as reversal of decrease in food consumption at 1.2 microg/g, po administered once daily via oral gavage for 7 consecutive days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA5164476 | F | Anti-colitis activity against DSS-induced C57BL/6 mouse model of acute colitis assessed as reduction in -cryptitis by measuring epithelial change scores at 1.2 microg/g, po administered once daily via oral gavage for 7 consecutive days by hematoxyin-eosin staining based histopathological analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA5164477 | B | Agonist activity at AhR in human AZ-AHR reporter cells derived from human HepG2 cells assessed as induction of AHRR mRNA expression at 1 uM incubated for 4 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA5164478 | B | Agonist activity at AhR in human LS180 cells assessed as induction of AHRR mRNA expression at 1 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA5164479 | B | Agonist activity at AhR in human LS180 cells assessed as induction of CYP1A1 mRNA expression at 1 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA5164480 | B | Displacement of fluorescence labeled ligand from human PXR ligand binding domain by Lanthascreen TR-FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA5164481 | B | Agonist activity at AhR (unknown origin) transfected in human AZ-AHR reporter cells derived from human HepG2 cells incubated for 4 hrs by luciferase reporter gene assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 8. | ALA5164482 | B | Agonist activity at human PXR transfected in human LS180 cells cotransfected with luciferase reporter plasmid p2A4-Luc assessed as transcriptional activity incubated for 24 hrs by luciferase reporter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5164483 | B | Agonist activity at androgen receptor (unknown origin) transfected in human AIZ-AR reporter cells derived from human 22Rv1 cells assessed as increase in luciferase activity at 100 uM incubated for 24 hrs by luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA5164484 | B | Agonist activity at Glucocorticoid receptor (unknown origin) transfected in human AZ-GR reporter cells derived from HeLa cells assessed as increase in luciferase activity at 100 uM incubated for 24 hrs by luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA5164485 | B | Agonist activity at AhR (unknown origin) transfected in human AZ-AHR reporter cells derived from human HepG2 cells assessed as relative efficacy incubated for 4 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 12. | ALA5164486 | B | Displacement of [3H]TCDD from mouse AhR expressed in mouse Hepa1c1c7 cells cytosol incubated for 2 hrs by competitive radioligand binding assay | Mus musculus | 3 | subcellular format | Scientific Literature | ||
| 13. | ALA5164487 | B | Agonist activity at AhR in human LS180 cells assessed as induction of nuclear translocation at 1 uM incubated for 90 mins by DAPI staining based confocal fluorescence microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA5164488 | B | Agonist activity at AhR in human LS180 cell lysates assessed as induction of AhR-ARNT heterodimerization at 1 uM incubated for 90 mins by co-immunoprecipitation assay | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
| 15. | ALA5164489 | B | Agonist activity at AhR in human LS180 cells assessed as binding of AhR to CYP1A1 promoter gene at 1 uM incubated for 90 mins by chromatin immunoprecipitation assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA5164490 | B | Agonist activity at AhR in human AZ-AHR reporter cells derived from human HepG2 cells assessed as induction of CYP1A1 mRNA expression at 1 uM incubated for 4 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA5164491 | B | Agonist activity at AhR in human LS180 cells assessed as induction of CYP1A1 mRNA expression at 1 uM incubated for 4 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA5164492 | B | Agonist activity at AhR in human LS180 cells assessed as induction of AHRR mRNA expression at 1 uM incubated for 4 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA5164493 | B | Agonist activity at AhR in human AZ-AHR reporter cells derived from human HepG2 cells assessed as induction of CYP1A1 mRNA expression at 1 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA5164494 | B | Agonist activity at AhR in human AZ-AHR reporter cells derived from human HepG2 cells assessed as induction of AHRR mRNA expression at 1 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature |
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