# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5141518 | T | Cytotoxicity against human LAD2 cells assessed as reduction in cell viability at 10 uM incubated for 24 hrs by Cell Counting Kit assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
2. | ALA5141519 | F | Anti-pseudo allergic activity in human LAD2 cells assessed as inhibition of C48/80-induced beta-hexosaminidase release at 0.1 to 10 uM pretreated for 30 mins followed by C48/80 addition measured after 30 mins | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
3. | ALA5141520 | F | Anti-pseudo allergic activity in human LAD2 cells assessed as decrease in C48/80-induced calcium intracellular mobilization at 10 uM by fluorescence based assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
4. | ALA5141521 | F | Anti-pseudo allergic activity in human LAD2 cells assessed as inhibition of C48/80-induced beta-hexosaminidase release | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
5. | ALA5141522 | F | Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis mouse model assessed as body temperature loss at 10 mg/kg followed by C48/80 administration intravenously after 30 mins post-compound administration measured every 5 mins for 30 mins | Mus musculus | 3 | organism-based format | Scientific Literature | ||
6. | ALA5141523 | F | Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis mouse model assessed as reduction in serum histamine level at 1 to 10 mg/kg followed by C48/80 administration intravenously after 30 mins post-compound administration measured every 5 mins for 30 mins by LC/MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
7. | ALA5141524 | F | Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis mouse model assessed as increase in local tissue edema vascular permeability at 1 to 10 mg/kg followed by C48/80 administration after 30 mins post-compound administration measured every 5 mins for 30 mins | Mus musculus | 3 | organism-based format | Scientific Literature | ||
8. | ALA5141525 | F | Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis C57 mouse model assessed as reduction in paw thickness rate at 0 to 1 mg/kg followed by C48/80 intravenously administration after 15 mins by Evans blue method | Mus musculus | 3 | organism-based format | Scientific Literature | ||
9. | ALA5141526 | F | Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis mouse model assessed as decrease in degranulation level at 0 to 1 mg/kg followed by C48/80 addition measured after 45 mins by FITC-avidin staining based laser scanning confocal microscopy | Mus musculus | 3 | organism-based format | Scientific Literature | ||
10. | ALA5141527 | F | Antagonist activity at MRGPRX2 (unknown origin) expressed in HEK293 cells assessed as inhibition of calcium mobilization at upto 10 uM | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
11. | ALA5141528 | F | Anti-pseudo allergic activity in HEK293 cells expressing H1R assessed as inhibition of histamine induced calcium release at 0 to 10 uM | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
12. | ALA5141529 | F | Anti-pseudo allergic activity in HEK293 cells assessed as prevention of calcium entry in presence of emodin at 0 to 10 uM | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA5141530 | F | Anti-pseudo allergic activity against passive cutaneous anaphylaxis-induced mouse model assessed as systemic symptoms at 1 to 10 mg/kg followed by C48/80 administration after 30 mins post-compound administration measured every 5 mins for 30 mins | Mus musculus | 3 | organism-based format | Scientific Literature | ||
14. | ALA5141531 | F | Anti-pseudo allergic activity against passive cutaneous anaphylaxis-induced C57 mouse model assessed as reduction in C48/80-induced extravasation rate at 0 to 1 mg/kg followed by C48/80 intravenously administration after 15 mins by Evans blue method | Mus musculus | 3 | organism-based format | Scientific Literature | ||
15. | ALA5141532 | F | Anti-pseudo allergic activity in human LAD2 cells assessed as inhibition of C48/80-induced histamine release at 0.1 to 10 uM pretreated for 30 mins followed by C48/80 addition measured after 30 mins by HPLC-MS analysis | Homo sapiens | 12 | cell-based format | Scientific Literature |