| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5147844 | T | Toxicity in CD-1 mouse assessed as appearance of lesions in heart at 4 mg/kg, ip administered daily for 6 days by H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA5147845 | B | Antagonist activity against Streptococcus pneumoniae D39-pcomX-lacZ strain expressing ComD1 receptor assessed as inhibition of ComD1 receptor activity by beta-galactosidase reporter gene assay | Streptococcus pneumoniae | 34 | assay format | Scientific Literature | ||
| 3. | ALA5147847 | B | Agonist activity against Streptococcus pneumoniae TIGR4-pcomX-lacZ strain expressing ComD2 receptor assessed as activation of ComD2 receptor activity by beta-galactosidase reporter gene assay | Streptococcus pneumoniae | 17 | assay format | Scientific Literature | ||
| 4. | ALA5147848 | B | Antagonist activity against CSP1-mediated pneumolysin release in Streptococcus pneumoniae D39 assessed as inhibition of autolytic release of pneumolysin at 46 to 368 nM in presence of CSP1 by Western blot analysis | Streptococcus pneumoniae | 1 | assay format | Scientific Literature | ||
| 5. | ALA5147849 | B | Antagonist activity against CSP2-mediated pneumolysin release in Streptococcus pneumoniae TIGR4 assessed as inhibition of autolytic release of pneumolysin at 46 to 368 nM in presence of CSP2 by Western blot analysis | Streptococcus pneumoniae | 1 | single protein format | Scientific Literature | ||
| 6. | ALA5147850 | T | Hemolytic activity against sheep RBC assessed as hemolysis using compound treated Streptococcus pneumoniae D39 cultured PLY supernatant at 46 to 368 nM incubated for 30 mins | Ovis aries | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5147851 | T | Hemolytic activity against sheep RBC assessed as hemolysis using compound treated Streptococcus pneumoniae TIGR4 cultured PLY supernatant at 46 to 368 nM incubated for 30 mins | Ovis aries | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5147852 | T | Toxicity in Streptococcus pneumoniae D39 infected CD-1 mouse model assessed as mortality at 4 mg/kg,iv measured after 120 hrs post infection | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5147853 | T | Toxicity in Streptococcus pneumoniae TIGR4 infected CD-1 mouse model assessed as mortality at 4 mg/kg,iv measured after 72 hrs post | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5147854 | F | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae D39 infected in CD-1 mouse assessed as reduction in bacterial burden in mouse lung at 4 mg/kg,iv measured after 48 hrs post infection | Streptococcus pneumoniae | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA5147855 | F | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae D39 infected in CD-1 mouse assessed as reduction in bacterial burden in mouse spleen at 4 mg/kg,iv measured after 48 hrs post infection | Streptococcus pneumoniae | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5147856 | F | Antibacterial activity against kanamycin-resistant Streptococcus pneumoniae TIGR4 infected in CD-1 mouse assessed as reduction in bacterial burden in mouse lung at 4 mg/kg,iv measured after 48 hrs post infection | Streptococcus pneumoniae | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5147857 | F | Antibacterial activity against kanamycin-resistant Streptococcus pneumoniae TIGR4 infected in CD-1 mouse assessed as reduction in bacterial burden in mouse spleen at 4 mg/kg,iv measured after 48 hrs post infection | Streptococcus pneumoniae | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5147858 | A | Stability of the compound in CD-1 mouse assessed as drug degradation at 50 ug, iv by IVIS spectrum in vivo imaging analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA5147859 | T | Toxicity in CD-1 mouse assessed as increase in body weight at 4 mg/kg, ip administered daily for 6 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5147860 | T | Toxicity in CD-1 mouse assessed as appearance of lesions in spleen at 4 mg/kg, ip administered daily for 6 days by H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5147861 | T | Toxicity in CD-1 mouse assessed as appearance of lesions in kidney at 4 mg/kg, ip administered daily for 6 days by H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5147862 | T | Toxicity in CD-1 mouse assessed as appearance of lesions in lung at 4 mg/kg, ip administered daily for 6 days by H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5147863 | T | Toxicity in CD-1 mouse assessed as appearance of lesions in liver at 4 mg/kg, ip administered daily for 6 days by H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature |
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