# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5133250 | B | Inhibition of BACE1 (unknown origin) | Homo sapiens | 15 | ALA5131410 | single protein format | Scientific Literature | |
2. | ALA5133251 | B | Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutation | Homo sapiens | 15 | ALA5131410 | cell-based format | Scientific Literature | |
3. | ALA5133252 | P | Dissociation constant, pKa of compound by UV-metric spectrophotometric analysis | 15 | ALA5131410 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5133253 | A | Efflux ratio of apparent permeability across basolateral to apical membrane to apical to basolateral membrane in pig LLC-PK1 cells expressing human MDR1 at 1 uM | Sus scrofa | 15 | ALA5131410 | cell-based format | Scientific Literature | |
5. | ALA5133254 | A | Efflux ratio of apparent permeability across basolateral to apical membrane to apical to basolateral membrane in pig LLC-PK1 cells expressing rat MDR1 at 1 uM | Sus scrofa | 15 | ALA5131410 | cell-based format | Scientific Literature | |
6. | ALA5133256 | T | Inhibition of human ERG expressed in HEK cells by voltage clamp assay | Homo sapiens | 4 | ALA5131410 | cell-based format | Scientific Literature | |
7. | ALA5133257 | F | Antialzheimer activity against in rat assessed as decrease in amyloid beta 40 in CSF at 10 mg/kg, po and measured after 3 hrs relative to control | Rattus norvegicus | 9 | ALA5131410 | organism-based format | Scientific Literature | |
8. | ALA5133258 | T | Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assay | Homo sapiens | 14 | ALA5131410 | cell membrane format | Scientific Literature | |
9. | ALA5133259 | P | Lipophilicity, log D of compound at pH 7 by HPLC analysis | 14 | ALA5131410 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA5133260 | A | Efflux ratio of apparent permeability across basolateral to apical membrane to apical to basolateral membrane in pig LLC-PK1 cells expressing human MDR1 at 0.1 uM | Sus scrofa | 1 | ALA5131410 | cell-based format | Scientific Literature | |
11. | ALA5133261 | A | Efflux ratio of apparent permeability across basolateral to apical membrane to apical to basolateral membrane in pig LLC-PK1 cells expressing rat MDR1 at 0.1 uM | Sus scrofa | 1 | ALA5131410 | cell-based format | Scientific Literature | |
12. | ALA5133262 | A | Free drug concentration in human plasma | Homo sapiens | 3 | ALA5131410 | cell-free format | Scientific Literature | |
13. | ALA5133263 | A | Free drug concentration in cynomolgus monkey plasma | Macaca fascicularis | 3 | ALA5131410 | cell-free format | Scientific Literature | |
14. | ALA5133264 | A | Free drug concentration in rat plasma | Rattus norvegicus | 3 | ALA5131410 | cell-free format | Scientific Literature | |
15. | ALA5133265 | F | Antialzheimer activity against in po dosed rat assessed as decrease in amyloid beta 40 in CSF measured after 3 hrs | Rattus norvegicus | 3 | ALA5131410 | organism-based format | Scientific Literature | |
16. | ALA5133266 | F | Antialzheimer activity against in po dosed rat assessed as plasma concentration required to 50 % decrease in amyloid beta 40 in CSF measured after 3 hrs | Rattus norvegicus | 3 | ALA5131410 | organism-based format | Scientific Literature | |
17. | ALA5133267 | A | Ratio of drug level in brain to plasma in rat | Rattus norvegicus | 3 | ALA5131410 | cell-free format | Scientific Literature | |
18. | ALA5133268 | F | Antialzheimer activity against in po dosed rhesus monkey assessed as decrease in amyloid beta 40 in CSF measured after 3 hrs | Macaca mulatta | 3 | ALA5131410 | organism-based format | Scientific Literature | |
19. | ALA5133269 | F | Antialzheimer activity against in po dosed rhesus monkey assessed as plasma concentration required to 50 % decrease in amyloid beta 40 in CSF measured after 3 hrs | Macaca mulatta | 3 | ALA5131410 | organism-based format | Scientific Literature | |
20. | ALA5133273 | B | Inhibition of human cathepsin D | Homo sapiens | 1 | ALA5131410 | single protein format | Scientific Literature |