| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5155261 | B | Inhibition of PI3Kgamma (unknown origin) in rhMPC1 stimulated human THP-1 cells assessed as reduction in Akt phosphorylation level at Ser473 residue preincubated for 60 mins followed by rhMCP-1 stimulation and measured after 2 mins by AlphaLisa assay | Homo sapiens | 53 | cell-based format | Scientific Literature | ||
| 2. | ALA5155264 | B | Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in presence of ATP by ADP-glo assay | Homo sapiens | 53 | single protein format | Scientific Literature | ||
| 3. | ALA5155265 | A | Time dependent inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 30 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 47 | microsome format | Scientific Literature | ||
| 4. | ALA5155266 | A | Metabolic stability in human hepatocytes assessed as intrinsic clearance per 10^6 cells at 0.5 uM by LC-MS/MS analysis | Homo sapiens | 53 | cell-based format | Scientific Literature | ||
| 5. | ALA5155267 | A | Metabolic stability in rat hepatocyte assessed as intrinsic clearance per 10^8 cells at 0.5 uM by LC-MS/MS analysis | Rattus norvegicus | 53 | cell-based format | Scientific Literature | ||
| 6. | ALA5155269 | B | Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in presence of ATP by ADP-glo assay | Homo sapiens | 49 | single protein format | Scientific Literature | ||
| 7. | ALA5155270 | B | Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in presence of ATP by ADP-glo assay | Homo sapiens | 49 | single protein format | Scientific Literature | ||
| 8. | ALA5155271 | B | Selectivity ratio of IC50 for inhibition of PI3Kalpha (unknown origin) to IC50 for inhibition of PI3Kgamma (unknown origin) | Homo sapiens | 49 | assay format | Scientific Literature | ||
| 9. | ALA5155272 | B | Selectivity ratio of IC50 for inhibition of PI3Kdelta (unknown origin) to IC50 for inhibition of PI3Kgamma (unknown origin) | Homo sapiens | 42 | assay format | Scientific Literature |
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